Cronemberger Sebastião, Veloso Artur W, Pereira Maria Valeria C, Leão de Lima Felipe, Gonçalves da Silva Alexandre Higino, de Figueiredo Barbosa Luciana, Milhomens Eduardo Gutemberg, Martins Márcio Placedino
Glaucoma Service Professor Nassim Calixto, Hospital São Geraldo, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Anesthesiologist of The Glaucoma Service Professor Nassim Calixto, Belo Horizonte, Brazil.
Front Med (Lausanne). 2025 Jun 26;12:1520706. doi: 10.3389/fmed.2025.1520706. eCollection 2025.
To quantitatively analyze intraocular pressure (IOP) alongside clinical and morphometric findings in a cohort of children with Peters' anomaly (PA).
This single-center retrospective study included a series of 46 children with PA. Glaucoma diagnosis in a subset was based on abnormal values of IOP, horizontal corneal diameter (HCD), or axial length (AL), individually or combined, compared to pediatric controls utilizing age-specific normative data. Patients were clinically classified into Peters I, II, III, and Peters-plus syndrome. Ultrasound biomicroscopy (UBM) was performed in 10 children.
The cohort of 46 children comprised 27 males and 19 females. All presented with central discoid corneal opacities; 33 cases were bilateral, 13 unilateral. Clinical classifications included 26 Peters I, 10 Peters II, 7 Peters III, and 3 Peters-plus syndrome. In the 29 children analyzed for biometrics, the median age at diagnosis was 7 months (IQR: 1.00-21.00). Median AL was 20.84 mm (IQR: 19.36-22.47 mm) for OD and 20.19 mm (IQR: 18.67-24.05 mm) for OS. Median HCD was 11.5 mm (IQR: 10.50-12.50 mm) for OD and 11.5 mm (IQR: 10.50-13.00 mm) for OS. Glaucoma was diagnosed in 14 patients (48.3%). A significant increase in glaucoma prevalence was observed in children >6 months old (53.6%) compared to those 0-6 months old (26.7%) ( = 0.03).
HCD and AL in PA often remain within normal limits, suggesting unique corneal biomechanics. Glaucoma in PA frequently manifests after 6 months of age, necessitating continuous monitoring.
对一组彼得斯异常（PA）患儿的眼压（IOP）以及临床和形态学检查结果进行定量分析。
这项单中心回顾性研究纳入了46例PA患儿。部分患儿的青光眼诊断是基于眼压、水平角膜直径（HCD）或眼轴长度（AL）的异常值，单独或综合与使用年龄特异性标准数据的儿科对照组进行比较。患者临床分为彼得斯I型、II型、III型和彼得斯综合征加型。对10例患儿进行了超声生物显微镜检查（UBM）。
46例患儿队列中，男性27例，女性19例。所有患儿均表现为中央盘状角膜混浊；33例为双侧，13例为单侧。临床分类包括26例彼得斯I型、10例彼得斯II型、7例彼得斯III型和3例彼得斯综合征加型。在分析生物测量数据的29例患儿中，诊断时的中位年龄为7个月（四分位间距：1.00 - 21.00）。右眼的中位眼轴长度为20.84毫米（四分位间距：19.36 - 22.47毫米），左眼为20.19毫米（四分位间距：18.67 - 24.05毫米）。右眼的中位水平角膜直径为11.5毫米（四分位间距：10.50 - 12.50毫米），左眼为11.5毫米（四分位间距：10.50 - 13.00毫米）。14例患者（48.3%）被诊断为青光眼。与0 - 6个月大的患儿（26.7%）相比，6个月以上患儿的青光眼患病率显著增加（53.6%）（P = 0.03）。
PA患儿的HCD和AL通常保持在正常范围内，提示角膜生物力学具有独特性。PA患儿的青光眼常在6个月龄后出现，需要持续监测。
