Chojdak-Łukasiewicz Justyna, Kołtuniuk Aleksandra, Sawicka Ewa, Pokryszko-Dragan Anna
Department of Neurology, Wroclaw Medical University, Wrocław, Poland.
Department of Nursing, Wroclaw Medical University, Wrocław, Poland.
Front Immunol. 2025 Jun 26;16:1545430. doi: 10.3389/fimmu.2025.1545430. eCollection 2025.
Adherence to disease-modifying therapies (DMTs) in multiple sclerosis (MS) is crucial for effective treatment. Understanding the patients' perspective and identification of factors influencing adherence to treatment may allow improved disease management.
This study attempted to evaluate adherence to DMTs in people with MS and explore potential patient-related factors influencing level of adherence.
121 patients with relapsing-remitting MS (90% women, aged 34.0 ± 10 years participated in the online self-reported survey, which included: Adherence in Chronic Diseases scale (ACDS), Patient health questionnaire (PHQ-9) as a measure of depression, Modified Fatigue Impact Scale (MFSI), Perceived Stress Scale (PSS-10), Acceptance of Illness Scale (AIS), and a questionnaire about demographics and basic patient-reported clinical data.
The ACDS results comprised between 9 and 28 points, with a mean value of 24.0 ± 3.8, indicating a moderate level of adherence. Fatigue was reported by 70% of patients and the results of MFIS showed significant correlation with ACDS (R=-0.260; p=0.004) and AIS score (R=0.487; p <0.001). Relationships were found between the results of AIS and PHQ-9 and PSS-10 but none of them was associated with ACDS, and neither were demographic data.
The adherence to treatment among MS patients is moderate and significantly associated with fatigue. Evaluating the level of adherence and the patients' psychosocial condition may contribute to personalized and optimal therapeutic approach.
坚持使用改善病情的疗法（DMTs）对多发性硬化症（MS）的有效治疗至关重要。了解患者的观点并识别影响治疗依从性的因素可能有助于改善疾病管理。
本研究试图评估MS患者对DMTs的依从性，并探讨影响依从水平的潜在患者相关因素。
121例复发缓解型MS患者（90%为女性，年龄34.0±10岁）参与了在线自我报告调查，该调查包括：慢性病依从性量表（ACDS）、作为抑郁测量指标的患者健康问卷（PHQ-9）、改良疲劳影响量表（MFSI）、感知压力量表（PSS-10）、疾病接受量表（AIS），以及一份关于人口统计学和患者报告的基本临床数据的问卷。
ACDS结果在9至28分之间，平均值为24.0±3.8，表明依从性处于中等水平。70%的患者报告有疲劳感，MFSI结果与ACDS（R=-0.260；p=0.004）和AIS评分（R=0.487；p<0.001）显示出显著相关性。发现AIS与PHQ-9和PSS-10的结果之间存在关联，但它们均与ACDS无关，人口统计学数据也与ACDS无关。
MS患者的治疗依从性处于中等水平，且与疲劳显著相关。评估依从水平和患者的心理社会状况可能有助于采取个性化和优化的治疗方法。
