Zanga Gisela, Drzewiscki Estefania, Tagliani Paula, Smietniansky Maximiliano, Esnaola Y Rojas Maria M, Caruso Diego
Department of Neurology, César Milstein Hospital, associated with University of Buenos Aires, La Rioja 951, Buenos Aires, C1221ACI, Argentina.
Department of Neurology, César Milstein Hospital, associated with University of Buenos Aires, Buenos Aires, Argentina.
Ther Adv Neurol Disord. 2021 Oct 5;14:17562864211031099. doi: 10.1177/17562864211031099. eCollection 2021.
In multiple sclerosis (MS), non-adherence/non-persistence is related to suboptimal response to treatment, including disease relapses and the need for more expensive healthcare. The aim of this study was to identify predictors related to adherence to disease modifying therapies (DMTs) in a cohort of Argentinian MS patients.
We conducted a cross-sectional study at the National Medical Care Program from Argentina. MS patients with at least one claim for a DMT from 1 January 2017 to 1 October 2017 were identified. A telephone survey was performed to assess clinical and demographic factors. The medication possession ratio (MPR) was used to estimate adherence; MPR <80% defined non-adherence. Associations were studied using a logistic regression model.
Our database included 648 MS patients. A total of 360 patients (60% females, mean age 55.3 years) accepted to participate. Of these, 308 (85.5%) patients were receiving DMT at the time of the survey. Some 198 (63.7%) were receiving injectable therapies. Optimal adherence was 47.7%. Adherence was associated with oral medication [odds ratio (OR) 1.83 95% confidence interval (CI) 1.13-3.00, = 0.014]. A factor related to oral drugs was higher educational level (OR 2.86 95%CI 1.41-5.81, = 0.004).
This real-world study showed better adherence and persistence on treatment with oral therapies in MS patients in Argentina.
在多发性硬化症（MS）中，不依从/不持续治疗与治疗效果欠佳有关，包括疾病复发以及需要更昂贵的医疗保健。本研究的目的是确定阿根廷MS患者队列中与疾病修饰疗法（DMTs）依从性相关的预测因素。
我们在阿根廷国家医疗保健计划中进行了一项横断面研究。确定了在2017年1月1日至2017年10月1日期间至少有一次DMT索赔记录的MS患者。通过电话调查评估临床和人口统计学因素。用药持有率（MPR）用于评估依从性；MPR<80%定义为不依从。使用逻辑回归模型研究相关性。
我们的数据库包括648例MS患者。共有360例患者（60%为女性，平均年龄55.3岁）同意参与。其中，308例（85.5%）患者在调查时正在接受DMT治疗。约198例（63.7%）接受注射疗法。最佳依从率为47.7%。依从性与口服药物有关[比值比（OR）1.83，95%置信区间（CI）1.13 - 3.00，P = 0.014]。与口服药物相关的一个因素是教育水平较高（OR 2.86，95%CI 1.41 - 5.81，P = 0.004）。
这项真实世界研究表明，阿根廷MS患者对口服疗法的依从性和持续性更好。
