Major Julia R, Warren Claire A, Rowley Paul A
Department of Biological Sciences, University of Idaho, Moscow, ID, USA.
Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID, 83844, USA.
Med Mycol Case Rep. 2025 Jun 21;49:100715. doi: 10.1016/j.mmcr.2025.100715. eCollection 2025 Sep.
Onychomycosis, a common fungal nail infection, is typically caused by dermatophytes or species, but rare fungal pathogens can also be involved. We describe a 20-year-old woman with persistent nail shedding who was unresponsive to standard antifungal treatments. Microscopic nail examination, fungal culture, and ITS sequencing repeatedly identified the presence of (formerly ), a dimorphic yeast more often associated with systemic bloodstream infections and not previously identified in patients with onychomycosis. Susceptibility testing revealed the resistance of isolates to multiple antifungal azoles, complicating future treatment strategies for the patient. Commonly found in hydrocarbon-rich environments and an important organism for biotechnology, has industrial applications but is also capable of causing opportunistic infections in vulnerable patient populations. This case highlights the importance of thorough microbial identification and susceptibility testing in cases of treatment-resistant onychomycosis.
甲癣是一种常见的指甲真菌感染，通常由皮肤癣菌或其他菌种引起，但罕见的真菌病原体也可能涉及。我们描述了一名20岁持续脱甲的女性，她对标准抗真菌治疗无反应。指甲显微镜检查、真菌培养和ITS测序反复鉴定出存在（以前称为），一种双相酵母，更常与全身性血流感染相关，以前在甲癣患者中未被鉴定出。药敏试验显示分离株对多种抗真菌唑类耐药，使该患者未来的治疗策略复杂化。常见于富含碳氢化合物的环境中，是生物技术的重要生物体，具有工业应用，但也能够在易感患者群体中引起机会性感染。该病例突出了在治疗抵抗性甲癣病例中进行全面微生物鉴定和药敏试验的重要性。
