Plant-based Exosome Injections for Skin Wound Healing: Experimental Study.

BACKGROUND

This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds.

METHODS

A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration.

RESULTS

The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics.

CONCLUSIONS

The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications.