Adel Noury, Stankovic Nenad, Cervantes Gerardo, Gindi Amira, Shawky Lamiaa Mohamed
Private Practice, Cairo, Egypt.
Private Practice, Belgrade, Serbia.
Plast Reconstr Surg Glob Open. 2025 Jul 10;13(7):e6949. doi: 10.1097/GOX.0000000000006949. eCollection 2025 Jul.
This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds.
A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration.
The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics.
The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications.
本研究旨在评估植物源外泌体注射对皮肤伤口愈合的影响。
共纳入18只Wistar白化大鼠，随机分为2组。第一组在腹侧手部表面进行手术刀切口，不进行任何额外治疗。第二组进行相同的切口，随后在伤口部位注射植物源外泌体。在基线以及第7天和第14天收集组织样本，用于伤口愈合的组织学评估。采用苏木精-伊红染色和Masson三色染色评估上皮厚度、胶原沉积和炎性细胞浸润。
与对照组相比，接受外泌体注射的组表现出显著增强的伤口愈合反应。组织学分析显示上皮厚度增加、炎性细胞计数减少以及胶原沉积增加且结构排列更有序，表明组织修复加速。到第14天，用外泌体治疗的伤口显示出形成良好的上皮且炎症显著减轻，突出了植物源外泌体在调节伤口愈合动态方面的治疗潜力。
将植物源外泌体注入皮肤伤口可显著改善愈合过程。这些发现表明外泌体疗法可能增强组织再生并加速恢复，使其成为优化伤口管理和修复的一种有前景的方法。有必要进一步研究以探索其更广泛的临床应用。
