Morley Alyssia, Koh Chung-Kay, Gonzalez Miguel
Department of Medicine, Department of Pathology, Advocate Lutheran General Hospital, Park Ridge, IL 60068-1143, USA.
JCEM Case Rep. 2025 Jul 10;3(8):luaf149. doi: 10.1210/jcemcr/luaf149. eCollection 2025 Aug.
Malignant struma ovarii (MSO) is a rare malignant teratoma of the ovary composed predominantly of malignant thyroid tissue, often resembling papillary or follicular thyroid carcinoma. We present a case of Stage 1A MSO, in remission 5 years post-treatment, alongside a review of the literature. The patient, who presented with right-sided abdominal pain, had imaging that revealed a right adnexal mass. Pathology confirmed papillary thyroid carcinoma (PTC) confined to the right ovary. Surveillance included computed tomography (CT) scans and transvaginal ultrasounds, all negative for recurrence at 5 years. A literature review underscores the importance of pathology in diagnosing MSO, with treatment dependent on tumor aggressiveness, metastasis, and fertility concerns. Surgery, sometimes combined with radioactive iodine ablation, is the primary treatment. High survival rates are reported regardless of treatment approach, but limited data hinder the standardized guidelines, highlighting the need for continued case reporting.
恶性卵巢甲状腺肿(MSO)是一种罕见的卵巢恶性畸胎瘤,主要由恶性甲状腺组织构成,常类似乳头状或滤泡状甲状腺癌。我们报告一例1A期MSO病例,治疗后5年病情缓解,并对相关文献进行综述。该患者因右侧腹痛就诊,影像学检查发现右侧附件区肿块。病理证实为局限于右侧卵巢的乳头状甲状腺癌(PTC)。监测包括计算机断层扫描(CT)和经阴道超声检查,5年时所有检查均未发现复发迹象。文献综述强调了病理检查在MSO诊断中的重要性,治疗取决于肿瘤的侵袭性、转移情况以及生育问题。手术有时联合放射性碘消融是主要治疗方法。无论采用何种治疗方法,报告的生存率都很高,但数据有限阻碍了标准化指南的制定,凸显了持续病例报告的必要性。