Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Department of Laboratories, Seattle Children's Hospital, Seattle, WA, 98105, USA.
Endocr Pathol. 2023 Dec;34(4):455-460. doi: 10.1007/s12022-023-09789-7. Epub 2023 Oct 21.
Struma ovarii is a well-known ovarian teratoma made up of benign thyroid tissue. These lesions demonstrate variable, normal architecture and normal thyroid immunohistochemical staining with positivity for TTF1, PAX8, and thyroglobulin. Though most are benign, some of these lesions can also present with a malignant component. Within this article, we review the most common diagnostic malignancies including papillary thyroid carcinoma, strumal carcinoid, highly differentiated follicular thyroid carcinoma, and other thyroid carcinomas. We additionally review the use of TTF1 staining to assist in differentiating these lesions from surrounding gynecologic epithelium, which is imperative in making such diagnoses. In highlighting these entities, we hope to provide practicing pathologists with an effective and concise review of these lesions to assist in more challenging cases of struma ovarii.
卵巢甲状腺肿是一种由良性甲状腺组织构成的、众所周知的卵巢畸胎瘤。这些病变表现出不同的、正常的结构，并且 TTF1、PAX8 和甲状腺球蛋白的免疫组织化学染色呈阳性，为良性。虽然大多数是良性的，但这些病变中的一些也可能存在恶性成分。在本文中，我们复习了最常见的诊断恶性肿瘤，包括甲状腺乳头状癌、甲状腺滤泡癌、甲状腺髓样癌和其他甲状腺癌。我们还复习了 TTF1 染色在鉴别这些病变与周围妇科上皮的作用，这对做出这些诊断至关重要。通过强调这些实体，我们希望为临床病理医生提供这些病变的有效和简洁的复习，以帮助处理更具挑战性的卵巢甲状腺肿病例。
