2型糖尿病患者循环中的前体蛋白激活因子和室管膜素相关蛋白1水平与胰岛素抵抗相关。

Circulating prosaposin and ependymin-related protein 1 levels are correlated with insulin resistance in type 2 diabetic patients.

作者信息

Ji Xin, Wang Yajing, Xu Sijia, Cao Ling, Fang Penghua, Zhang Zhenwen

机构信息

Department of Endocrinology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.

Department of Endocrinology, Northern Jiangsu People's Hospital, Yangzhou, China.

出版信息

Front Endocrinol (Lausanne). 2025 Jun 26;16:1519586. doi: 10.3389/fendo.2025.1519586. eCollection 2025.

DOI:10.3389/fendo.2025.1519586

PMID:40642507

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12240745/

Abstract

OBJECTIVE

Skeletal muscle and adipose tissues secrete myokines and adipokines to regulate energy metabolism. Experimental evidence indicates that prosaposin (PSAP) and ependymin-related protein 1 (EPDR1) are involved in the regulation of thermogenesis and energy metabolism. To our knowledge, little literature has been found dealing with PSAP and EPDR1 levels in type 2 diabetes mellitus (T2DM) patients. The aim of the study was to evaluate possible relationships between both peptide levels and insulin resistance indexes in type 2 diabetic subjects.

METHODS

The study groups consisted of 64 T2DM subjects and 22 normal controls. Serum PSAP and EPDR1 concentrations were determined using immunosorbent assay kits.

RESULTS

The serum PSAP (319.6 ± 78.38 vs. 207.2 ± 42.43, P<0.0001) and EPDR1 (7.988 ± 3.484 vs. 6.399 ± 3.788, P=0.0823) concentrations were higher in T2DM subjects than normal controls. In addition, positive correlations were found between: PSAP and fasting blood glucose (FBG) levels (r = 0.5004; P< 0.0001), PSAP and Hemoglobin A1c (HAb1c) (r = 0.4688; P< 0.0001), PSAP and C-peptide (r = 0.3981; P = 0.0003), PSAP and triglyceride-glucose index (TyG) (r = 0.2362; P< 0.0001), PSAP and homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.3314; P = 0.0035), PSAP and homeostasis model assessment of C-peptide resistance (HOMA-CR) (r = 0.5486; P< 0.0001), EPDR1 and insulin (r = 0.2291; P = 0.045), EPDR1 and HOMA-IR (r = 0.2462; P = 0.0309) in both T2DM and normal control subjects.

CONCLUSIONS

Our results indicated that T2DM individuals have higher serum PSAP and EPDR1 levels, and both peptide concentrations were positively correlative to insulin (INS) resistance levels. PSAP and EPDR1 levels may be taken as potential biomarkers to forecast the development of T2DM.

摘要

目的

骨骼肌和脂肪组织分泌肌动蛋白和脂肪因子以调节能量代谢。实验证据表明，prosaposin（PSAP）和室管膜素相关蛋白1（EPDR1）参与产热和能量代谢的调节。据我们所知，关于2型糖尿病（T2DM）患者中PSAP和EPDR1水平的文献很少。本研究的目的是评估2型糖尿病患者中这两种肽水平与胰岛素抵抗指标之间的可能关系。

方法

研究组由64名T2DM患者和22名正常对照组成。使用免疫吸附测定试剂盒测定血清PSAP和EPDR1浓度。

结果

T2DM患者的血清PSAP（319.6±78.38 vs. 207.2±42.43，P<0.0001）和EPDR1（7.988±3.484 vs. 6.399±3.788，P = 0.0823）浓度高于正常对照。此外，在T2DM患者和正常对照中均发现：PSAP与空腹血糖（FBG）水平呈正相关（r = 0.5004；P<0.0001），PSAP与糖化血红蛋白（HAb1c）呈正相关（r = 0.4688；P<0.0001），PSAP与C肽呈正相关（r = 0.3981；P = 0.0003），PSAP与甘油三酯-葡萄糖指数（TyG）呈正相关（r = 0.2362；P<0.0001），PSAP与胰岛素抵抗稳态模型评估（HOMA-IR）呈正相关（r = 0.3314；P = 0.0035），PSAP与C肽抵抗稳态模型评估（HOMA-CR）呈正相关（r = 0.5486；P<0.0001），EPDR1与胰岛素呈正相关（r = 0.2291；P = 0.045），EPDR1与HOMA-IR呈正相关（r = 0.2462；P = 0.0309）。