布比卡因诱导心脏毒性后静脉注射脂质乳剂的神经保护作用。
Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity.
作者信息
Doğukan Mevlüt, Yılmaz Nezir, Türk Ahmet, Tosun Fadime, Duran Mehmet, Bozkurt Zeliha
机构信息
Department of Anesthesiology and Reanimation, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey.
Department of Histology and Embryology, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey.
出版信息
Saudi J Anaesth. 2025 Jul-Sep;19(3):363-367. doi: 10.4103/sja.sja_810_24. Epub 2025 Jun 16.
BACKGROUND
This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.
METHODS
Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.
RESULTS
The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters ( < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.
CONCLUSION
ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.
背景
本研究旨在通过组织病理学分析，探讨静脉注射脂质乳剂（ILE）对布比卡因所致心脏毒性的保护作用。
方法
将28只成年雄性Wistar - 白化大鼠分为四组：假手术组（A组）、ILE组（B组）、布比卡因组（C组）和布比卡因 + ILE组（D组）。C组和D组通过持续输注布比卡因诱导神经毒性。B组和D组给予ILE。对脑组织进行组织学检查并评估凋亡指数。
结果
C组的凋亡指数显著更高，但D组给予ILE后这些参数明显降低（<0.05）。组织病理学分析显示，ILE减轻了D组的水肿和神经元变性。
结论
ILE通过改善血流动力学稳定性和减少细胞损伤，对布比卡因所致心脏毒性表现出神经保护作用。这表明ILE在处理局部麻醉药全身毒性方面具有潜在的治疗作用。
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