Favitta Salvatore Fabrizio, Santolamazza Danilo, Luca Ersilia, De Cicco Roberto, Aceto Paola
Dipartimento di Scienze dell'emergenza, anestesiologiche e della rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy.
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Saudi J Anaesth. 2025 Jul-Sep;19(3):368-374. doi: 10.4103/sja.sja_661_24. Epub 2025 Jun 16.
Bariatric surgery is a rapidly developing field and presents a challenge for anesthesia management, especially in the treatment of acute postoperative pain. Severely obese patients have a greater risk of intra and postoperative complications due to their cardiovascular and respiratory pathophysiological alterations. Excessive fat also alters the normal metabolism of analgesic drugs, in particular opioids, thus reducing their therapeutic range and increasing the risk of reaching toxic doses with accumulation and overdose effects. Nociception, in contrast to pain, is not a subjective experience but a physiological response to a nociceptive stimulus, which manifests as objective modifications in vital parameters. An increasing number of monitoring methods have been approved in recent years, especially developed for the detection of intraoperative nociception to enable better control of opioid titration. This review aimed to provide an overview of the main monitoring systems commercially available devices, which could be used to monitor nociception during bariatric surgery. Eighteen studies evaluating the most widespread nociception monitoring systems were analyzed. These studies were mostly conducted on patients undergoing abdominal laparoscopic surgery, which is comparable to bariatric surgery in terms of pain stimulation. Intraoperative and postoperative opioid consumption were compared between patients subject to nociceptive monitoring and those in whom analgesia was guided by their changes in vital parameters. Although the devices seem able to optimize the anesthetic management of these patients, studies on bariatric populations are scarce and do not allow us to state whether the routine use of these tools can modify the patient's clinical outcome.
减肥手术是一个快速发展的领域,对麻醉管理提出了挑战,尤其是在治疗术后急性疼痛方面。严重肥胖患者由于其心血管和呼吸生理病理改变,术中和术后并发症的风险更高。过多的脂肪还会改变镇痛药尤其是阿片类药物的正常代谢,从而缩小其治疗范围,并增加因蓄积和过量效应而达到中毒剂量的风险。与疼痛不同,伤害感受不是一种主观体验,而是对伤害性刺激的生理反应,表现为生命体征的客观变化。近年来,越来越多的监测方法得到认可,尤其是专门为检测术中伤害感受而开发的,以便更好地控制阿片类药物的滴定。本综述旨在概述市面上主要的监测系统,这些系统可用于在减肥手术期间监测伤害感受。分析了18项评估最广泛使用的伤害感受监测系统的研究。这些研究大多是在接受腹部腹腔镜手术的患者身上进行的,就疼痛刺激而言,腹部腹腔镜手术与减肥手术具有可比性。对接受伤害感受监测的患者和根据生命体征变化进行镇痛的患者的术中和术后阿片类药物消耗量进行了比较。尽管这些设备似乎能够优化这些患者的麻醉管理,但针对肥胖人群的研究很少,我们无法确定常规使用这些工具是否能改变患者的临床结局。