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唐氏综合征及相关阿尔茨海默病性痴呆患者中频率大于250赫兹的高频振荡。

High-frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia.

作者信息

Lisgaras Christos Panagiotis, Giménez Sandra, Carmona-Iragui María, Maure-Blesa Lucia, Blessing Esther, Fortea Juan, Osorio Ricardo S

机构信息

Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA.

The Nathan S. Kline Institute for Psychiatric Research, New York State Office of Mental Health, New York, USA.

出版信息

Alzheimers Dement. 2025 Jul;21(7):e70386. doi: 10.1002/alz.70386.

DOI:10.1002/alz.70386
PMID:40642994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12246959/
Abstract

INTRODUCTION

Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, promising biomarkers of epileptogenicity, such as high-frequency oscillations (HFOs >250 Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS.

METHODS

Wideband (0.1 to 500 Hz, 2048 Hz) polysomnography was performed using the international 10-20 system. HFOs were automatically detected during slow-wave sleep, followed by manual review.

RESULTS

Fourteen individuals with DS and five age-matched euploid controls were studied, with all DS cases showing HFOs. HFOs emerged before AD dementia and LOMEDS and showed hemispheric lateralization in asymptomatic but not symptomatic AD dementia cases. A trend toward increasing HFO rates with age in DS warrants further confirmation.

DISCUSSION

HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS.

HIGHLIGHTS

Wideband polysomnography reveals a new electrical abnormality in DS. HFOs precede AD dementia in DS. The occurrence of HFOs in DS is independent of an epilepsy diagnosis. HFOs showed hemispheric lateralization in asymptomatic DS cases. A trend of increased HFO rate with advancing age warrants further investigation.

摘要

引言

阿尔茨海默病（AD）痴呆症在唐氏综合征（DS）成年人中几乎具有完全的发病率，并且与唐氏综合征迟发性肌阵挛癫痫（LOMEDS）密切相关。然而，尚未对有前景的致痫性生物标志物进行研究，例如高频振荡（HFOs>250Hz）。本研究首次在唐氏综合征中使用宽带多导睡眠图来调查HFOs是否出现以及是否先于AD痴呆症和LOMEDS出现。

方法

使用国际10-20系统进行宽带（0.1至500Hz，2048Hz）多导睡眠图检查。在慢波睡眠期间自动检测HFOs，随后进行人工复查。

结果

研究了14名唐氏综合征患者和5名年龄匹配的正常对照者，所有唐氏综合征病例均显示有HFOs。HFOs在AD痴呆症和LOMEDS之前出现，并且在无症状但有症状的AD痴呆症病例中显示出半球侧化。唐氏综合征患者中HFOs发生率随年龄增加的趋势值得进一步证实。

讨论

HFOs是有前景的生物标志物，可能预测唐氏综合征成年人的症状性AD痴呆症。

要点

宽带多导睡眠图揭示了唐氏综合征中的一种新的电异常。HFOs先于唐氏综合征中的AD痴呆症出现。唐氏综合征中HFOs的出现与癫痫诊断无关。HFOs在无症状的唐氏综合征病例中显示出半球侧化。HFOs发生率随年龄增长而增加的趋势值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/ab3059ba298a/ALZ-21-e70386-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/d8501cbf8859/ALZ-21-e70386-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/c6c93eebf898/ALZ-21-e70386-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/5fef9c83fdcc/ALZ-21-e70386-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/51ea637bcb43/ALZ-21-e70386-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/53dd246886a3/ALZ-21-e70386-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/a9a910b384b3/ALZ-21-e70386-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/ab3059ba298a/ALZ-21-e70386-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/d8501cbf8859/ALZ-21-e70386-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/c6c93eebf898/ALZ-21-e70386-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/5fef9c83fdcc/ALZ-21-e70386-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/51ea637bcb43/ALZ-21-e70386-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/53dd246886a3/ALZ-21-e70386-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/a9a910b384b3/ALZ-21-e70386-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee1b/12246959/ab3059ba298a/ALZ-21-e70386-g006.jpg

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