Giménez Sandra, Vaqué-Alcázar Lídia, Zhu Nuole, Benejam Bessy, Arranz Javier, Maure-Blesa Lucia, Videla Laura, Carmona-Iragui Maria, Barroeta Isabel, Rebillat Anne-Sophie, Rodríguez-Baz Íñigo, Bejanin Alexandre, Arriola-Infante José Enrique, Bueno Ana, Fernandez Susana, Ribas Laia, Zsadanyi Sara E, Morcillo-Nieto Alejandra O, Alcolea Daniel, Lisgaras Christos Panagiotis, Blessing Esther, Osorio Ricardo S, Lleó Alberto, Fortea Juan
Multidisciplinary Sleep Unit, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB SANT PAU), Barcelona, Spain.
Sant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau (IIB SANT PAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Alzheimers Dement. 2025 Jul;21(7):e70400. doi: 10.1002/alz.70400.
Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum.
We studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography.
Adults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders.
In DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression.
Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.
唐氏综合征（DS）是阿尔茨海默病（AD）的一种遗传形式，睡眠障碍患病率很高，但缺乏关于患有DS和痴呆症的成年人的数据。我们旨在评估处于AD连续体各阶段的成年DS患者的睡眠情况。
我们研究了78名健康对照者以及229名成年DS患者（154名无症状，25名处于AD前驱期，75名患有AD），采用主观睡眠测量和夜间多导睡眠图进行客观评估。
与对照组相比，成年DS患者的睡眠质量更差，未被察觉的阻塞性睡眠呼吸暂停（OSA）患病率更高。在AD连续体各阶段，睡眠中断和OSA严重程度均增加。在DS组中，与年龄相关的慢波睡眠和快速眼动睡眠减少更为明显。主观睡眠测量未能发现睡眠障碍。
在DS中，AD与更严重的睡眠障碍和睡眠结构改变有关。然而，需要纵向研究来阐明方向性和疾病进展情况。
唐氏综合征（DS）与慢波睡眠（SWS）增加和快速眼动（REM）睡眠减少有关。在DS中，阻塞性睡眠呼吸暂停患病率沿阿尔茨海默病连续体增加。在DS中，与年龄相关的SWS和REM睡眠减少加速。主观睡眠测量无法检测出成年DS患者的睡眠障碍。
