Willis N, Clapham M
Clin Chim Acta. 1985 Aug 30;150(3):213-20. doi: 10.1016/0009-8981(85)90246-3.
Blood oxygen content calculated from haemoglobin concentration, measured haemoglobin oxygen saturation and measured oxygen tension was compared with three other methods of estimating oxygen content. These other methods were those of Van Slyke and Zander, which are direct methods, and a method using Kelman's equation to estimate the saturation from measured oxygen tension and hence content. The coefficients of correlation (corr coeff) (r) were 0.9050 (n = 22), 0.9919 (n = 24) and 0.9862 (n = 25) for the respective methods when compared with oxygen content calculated using measured saturation. The Van Slyke method proved to be imprecise in our hands. The direct measurement using the oxygen cuvette of Zander gave oxygen content values similar to those estimated from measured saturation. The oxygen content calculated from pO2 alone when compared to that derived from measured saturation had a corr coeff (r) of 0.9862 (n = 25), but the high residual standard deviation (So) of 6.939 ml/l indicates that the practice of calculating oxygen content from oxygen tension alone is imprecise. We conclude that oxygen content may be satisfactorily estimated by the Zander method when it becomes generally available, but until then the measurement of oxygen saturation is a necessary prerequisite to the estimation of blood oxygen content.
将根据血红蛋白浓度、测得的血红蛋白氧饱和度和测得的氧分压计算出的血氧含量与其他三种估算氧含量的方法进行了比较。其他方法分别是范斯莱克法和赞德法，这两种是直接方法，还有一种方法是使用凯尔曼方程根据测得的氧分压估算饱和度进而估算含量。与使用测得的饱和度计算出的氧含量相比，各方法的相关系数（corr coeff）（r）分别为0.9050（n = 22）、0.9919（n = 24）和0.9862（n = 25）。在我们手中，范斯莱克法被证明不够精确。使用赞德氧比色计进行的直接测量得出的氧含量值与根据测得的饱和度估算出的值相似。仅根据pO₂计算出的氧含量与根据测得的饱和度得出的氧含量相比，相关系数（r）为0.9862（n = 25），但6.939 ml/l的高剩余标准差（So）表明仅根据氧分压计算氧含量的做法不够精确。我们得出结论，赞德法在普遍可用时可令人满意地估算氧含量，但在此之前，测量氧饱和度是估算血氧含量的必要前提。
