Markey S P, Higa S, Shih M, Danforth D N, Tamarkin L
Clin Chim Acta. 1985 Aug 30;150(3):221-5. doi: 10.1016/0009-8981(85)90247-5.
A significant correlation (0.76) has been found between nighttime peak plasma melatonin levels and the 24-h urinary excretion totals for conjugated 6-hydroxymelatonin for a group of 22 women. This study validates the comparison of plasma levels of the hormone or urinary levels of its metabolite to assess pineal gland production of melatonin in humans.
在一组22名女性中，已发现夜间血浆褪黑素峰值水平与共轭6-羟基褪黑素的24小时尿排泄总量之间存在显著相关性（0.76）。这项研究验证了通过比较激素的血浆水平或其代谢物的尿液水平来评估人体松果体褪黑素分泌量的方法。
