Jiang Jingjing, Zhao Tong, Yin Yue, Han Mengyu, Wu Xi, Chen Yi
Department of Ophthalmology, China-Japan Friendship Hospital, Beijing City, 100029, China.
Department of Ophthalmology, Peking University People's Hospital, Beijing City, 100044, China.
Eur J Med Res. 2025 Jul 16;30(1):631. doi: 10.1186/s40001-025-02901-z.
What is known Occlusion with Bangerter filters designed with different translucent microscopic diffusers is an effective treatment for anisometropic amblyopia. What is new Bangerter filters were found to show an effect on slowing down ocular axial length (AL) growth. When rapid hyperopic reduction occurs in the non-amblyopic eye combined with persistently widening interocular AL differences, Bangerter filter application represents a more preferable alternative to patching for managing anisometropic amblyopia.
Bangerter filter occlusion is an effective clinical method for amblyopia treatment. This study aimed to compare the nonamblyopic eyes elongation and refraction change of patching and Bangerter filter occlusion in treating patients with anisometropic amblyopia and to further investigate the effect of Bangerter filter on axial length growth.
This retrospective study included 54 patients with anisometropic amblyopia categorized by initial treatment: patching group (n = 24) and Bangerter filter group (n = 30). Consecutive records of both the amblyopia and nonamblyopia eyes were reviewed from baseline before treatment onset to follow-up visits during or post-treatment, including best corrected visual acuity, pneumatic intraocular pressure, spherical equivalent refraction (SER), axial length (AL), corneal curvature, binocular visual function, and accommodative function. In addition, macrostructures of three different densities of Bangerter filters and diffusion optics technology lenses were observed and compared.
The nonamblyopic eyes in the Bangerter filter group had significantly lower AL increases from baseline (- 0.15 and - 0.20, respectively, P < 0.05) and significantly fewer SER reductions from baseline (0.45 and 0.57, respectively, P < 0.05) compared with the patching group at both two follow-up visits. The interocular AL difference between nonamblyopic and amblyopic eyes increased by 0.15 ± 0.27 mm in the occlusion group at the second follow-up (from baseline 0.23 ± 0.61 mm to second follow-up 0.38 ± 0.69 mm, P = 0.004), while it decreased by 0.18 ± 0.20 mm in the Bangerter filter group at the second follow-up (from baseline 0.72 ± 0.68 mm to second follow-up 0.54 ± 0.69 mm, P < 0.001).
Bangerter filter, as a traditional occlusion therapy, have been shown to effectively slow ocular AL growth thereby reducing interocular axial length disparity when compared to patching therapy in anisometropic amblyopia treatment. Rapid reduction of hyperopic refraction in non-amblyopic eyes combined with persistent increases in interocular AL difference may constitute a novel indication for Bangerter filter application.
已知情况 使用设计有不同半透明微观漫射器的班格特滤光片进行遮盖是治疗屈光参差性弱视的有效方法。新发现 研究发现班格特滤光片对减缓眼轴长度（AL）增长有作用。当非弱视眼快速远视性屈光不正降低，同时两眼间AL差异持续增大时，应用班格特滤光片是治疗屈光参差性弱视比遮盖更合适的选择。
班格特滤光片遮盖是一种有效的弱视临床治疗方法。本研究旨在比较遮盖和班格特滤光片遮盖治疗屈光参差性弱视患者时非弱视眼的眼轴伸长和屈光变化，并进一步研究班格特滤光片对眼轴长度增长的影响。
本回顾性研究纳入54例屈光参差性弱视患者，根据初始治疗方法分为：遮盖组（n = 24）和班格特滤光片组（n = 30）。回顾从治疗开始前的基线到治疗期间或治疗后的随访期间弱视眼和非弱视眼的连续记录，包括最佳矫正视力、气眼压、等效球镜度（SER）、眼轴长度（AL）、角膜曲率、双眼视觉功能和调节功能。此外，观察并比较了三种不同密度的班格特滤光片和扩散光学技术镜片的宏观结构。
与遮盖组相比，在两次随访时，班格特滤光片组的非弱视眼从基线起的AL增加显著更低（分别为-0.15和-0.20，P < 0.05），且从基线起的SER降低显著更少（分别为0.45和0.57，P < 0.05）。在第二次随访时，遮盖组非弱视眼与弱视眼之间的眼轴差异增加了0.15±0.27mm（从基线的水平0.23±0.61mm增加到第二次随访时的水平0.38±0.69mm，P = 0.004），而班格特滤光片组在第二次随访时减少了0.18±0.20mm（从基线的水平0.72±0.68mm减少到第二次随访时的水平0.54±0.69mm，P < 0.001）。
与遮盖疗法相比，班格特滤光片作为一种传统的遮盖疗法，已被证明能有效减缓眼轴增长，从而减少屈光参差性弱视治疗中的两眼间眼轴长度差异。非弱视眼远视性屈光不正的快速降低与两眼间眼轴差异的持续增加可能构成班格特滤光片应用的新指征。
