Munder Markus
Abteilung für Innere Medizin/Hämatologie und Internistische Onkologie, Diakonissen-Stiftungs-Krankenhaus Speyer, Paul-Egell-Str. 33, 67346, Speyer, Deutschland.
Z Rheumatol. 2025 Jul 9. doi: 10.1007/s00393-025-01678-0.
Chronic inflammation and disorders of immunoregulation are basic traits of inflammatory rheumatic diseases and also cofactors in the development and sequelae of plasma cell dyscrasias with associated gammopathy. Therefore, in cases of unclear rheumatological symptoms the possibility of an underlying monoclonal gammopathy of undetermined significance (MGUS) should always be considered. The thorough examination of patients with a monoclonal gammopathy is important to be able to differentiate between MGUS, monoclonal gammopathy of clinical significance (MGCS) and multiple myeloma.
慢性炎症和免疫调节紊乱是炎性风湿性疾病的基本特征，也是伴有相关丙种球蛋白病的浆细胞发育异常及其后遗症发展过程中的辅助因素。因此，对于风湿症状不明的病例，应始终考虑存在意义未明的单克隆丙种球蛋白病（MGUS）的可能性。对单克隆丙种球蛋白病患者进行全面检查，对于区分MGUS、具有临床意义的单克隆丙种球蛋白病（MGCS）和多发性骨髓瘤至关重要。
