Huang Xi, Pan Cun-Hui, Yin Fei, Peng Jing, Yang Li
Department of Pediatrics, Clinical Research Center of Children Neurodevelopmental Disabilities of Hunan Province, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Kaifu District, Changsha City, Hunan Province, China.
Cell Mol Neurobiol. 2025 Jul 11;45(1):68. doi: 10.1007/s10571-025-01592-8.
This review aims to investigate the potential role of estrogen in various mitochondrial diseases, such as Leber's Hereditary Optic Neuropathy and Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes, focusing on its effects on aging, oxidative stress, mitochondrial biogenesis, and mitophagy. Mitochondrial diseases have become important in modern medical research due to their complex genetic background and diverse clinical manifestations. Studies in recent years have shown that estrogen plays an essential role in physiological regulation and may also affect the health status of cells by regulating mitochondrial function, which in turn affects the occurrence and development of diseases. However, there is still a lack of systematic review of estrogen's specific mechanisms and roles in these diseases. This review will synthesize the relevant literature to explore the association between estrogen and mitochondrial diseases and its possible therapeutic prospects, aiming to provide a theoretical basis and reference for future research.
本综述旨在研究雌激素在各种线粒体疾病中的潜在作用，如Leber遗传性视神经病变、线粒体脑肌病伴乳酸酸中毒和卒中样发作，重点关注其对衰老、氧化应激、线粒体生物发生和线粒体自噬的影响。线粒体疾病因其复杂的遗传背景和多样的临床表现，在现代医学研究中变得日益重要。近年来的研究表明，雌激素在生理调节中起着至关重要的作用，还可能通过调节线粒体功能影响细胞的健康状态，进而影响疾病的发生和发展。然而，目前仍缺乏对雌激素在这些疾病中具体机制和作用的系统性综述。本综述将综合相关文献，探讨雌激素与线粒体疾病之间的关联及其可能的治疗前景，旨在为未来的研究提供理论依据和参考。
