Viñals F, Correa F, García-Rodríguez R, Tubau-Navarra A, Esparza M, Diaz L
Ultrasound Department, Sanatorio Alemán Clinic, Concepción, Chile.
Obstetrics Department, Faculty of Medicine, University of Concepción, Concepción, Chile.
Ultrasound Obstet Gynecol. 2025 Sep;66(3):347-352. doi: 10.1002/uog.29292. Epub 2025 Jul 11.
The aim of the present study was to describe abnormal anatomical features of the anterior (AC) and posterior (PC) complexes identified during basic ultrasound assessment of the fetal brain in cases diagnosed with partial agenesis of the corpus callosum (pACC).
This was a retrospective observational study of 22 fetuses diagnosed with pACC between January 2010 and June 2024. The cases were reviewed by fetal neurosonographers who evaluated the morphology of AC and PC structures visualized during basic axial fetal brain screening at 20-33 weeks' gestation in three different referral centers in Chile and Spain. All cases were also assessed independently by another fetal neurosonographer who was blinded to the original reports, using images, videoclips and three-dimensional volume datasets.
Regarding the structures that comprise the AC, the cavum septi pellucidi had an abnormal appearance in 20/22 cases and the anterior horn of the lateral ventricle had a dysmorphic pattern, characterized by being parallel to the midline, in 11/22 cases. PC abnormalities observed included widening of the interhemispheric fissure posteriorly in 20/22 cases, and absent callosal sulcus with no visualization of the corpus callosum crossing the midline in 19/22 cases. Observation of these PC abnormalities had a very high level of agreement between the original and the independent neurosonographers, ranging between 95% and 100%.
Evaluation of the AC and PC during the basic examination of the fetal brain could significantly improve the prenatal diagnosis of corpus callosum dysgenesis. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
本研究的目的是描述在诊断为胼胝体部分发育不全（pACC）的胎儿脑部基础超声评估过程中所发现的前连合（AC）和后连合（PC）复合体的异常解剖特征。
这是一项对2010年1月至2024年6月期间诊断为pACC的22例胎儿进行的回顾性观察研究。智利和西班牙的三个不同转诊中心的胎儿神经超声检查人员对这些病例进行了复查，他们评估了妊娠20 - 33周时胎儿脑部基础轴位筛查中所显示的AC和PC结构的形态。所有病例还由另一位对原始报告不知情的胎儿神经超声检查人员独立评估，使用图像、视频片段和三维容积数据集。
关于构成AC的结构，透明隔腔在22例中的20例呈现异常外观，侧脑室前角在22例中的11例具有畸形模式，其特征为与中线平行。观察到的PC异常包括22例中的20例半球间裂后部增宽，以及22例中的19例胼胝体沟缺失且未见胼胝体跨越中线。原始和独立的神经超声检查人员对这些PC异常的观察一致性非常高，范围在95%至100%之间。
在胎儿脑部基础检查过程中对AC和PC进行评估可显著提高胼胝体发育不全的产前诊断率。© 2025作者。《妇产科超声》由约翰·威利父子有限公司代表国际妇产科超声学会出版。
