Crosby L O, Kaplan F S, Pertschuk M J, Mullen J L
Clin Orthop Relat Res. 1985 Dec(201):271-7.
Changes in bone morphometry during chronic undernutrition were evaluated in 14 young women with anorexia nervosa (mean age +/- SEM = 25.5 +/- 4.4 yrs). Bone morphometry studies using the second metacarpal of the left hand showed significant depression for percent cortical area (p less than 0.05); cortical area (p less than 0.001) and combined cortical thickness (p less than 0.01) as compared to age, sex and race matched controls. A trend (p less than 0.10) was observed in study subjects for reductions in bone width and total area. Using percent cortical area (PCA) as the standard, subjects had mean cortical bone morphometry equivalent to 60-year-old women. Appendicular bone mass is significantly decreased in adults with anorexia nervosa. Anorexia nervosa should be considered in the differential diagnosis of osteopenia in young women, and serves as a model for studying the effects of chronic calorie and mineral malnutrition on bone remodeling at the time of attainment of peak bone mass.
对14名神经性厌食症年轻女性（平均年龄±标准误=25.5±4.4岁）进行了慢性营养不良期间骨形态计量学变化的评估。使用左手第二掌骨进行的骨形态计量学研究显示，与年龄、性别和种族匹配的对照组相比，皮质面积百分比（p<0.05）、皮质面积（p<0.001）和皮质总厚度（p<0.01）均显著降低。在研究对象中观察到骨宽度和总面积减少的趋势（p<0.10）。以皮质面积百分比（PCA）为标准，研究对象的平均皮质骨形态计量学相当于60岁女性。神经性厌食症成年患者的四肢骨量显著减少。在年轻女性骨质减少的鉴别诊断中应考虑神经性厌食症，它可作为研究慢性热量和矿物质营养不良对骨量峰值时骨重塑影响的模型。
