Mangalmurti Aman, Lukens John R
Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
J Exp Med. 2025 Oct 6;222(10). doi: 10.1084/jem.20250951. Epub 2025 Jul 11.
New work from Yang et al. (https://doi.org/10.1084/jem.20242296) provides an exhaustive study of a novel mouse model of NGLY1 deficiency, a devastating neurological disease, and implicates the cGAS-STING pathway in mediating key disease features which can be rescued using an orally administered STING antagonist.
