消除神经退行性疾病中的STING蛋白。
Taking the STING out of neurodegenerative disease.
作者信息
Mangalmurti Aman, Lukens John R
机构信息
Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
出版信息
J Exp Med. 2025 Oct 6;222(10). doi: 10.1084/jem.20250951. Epub 2025 Jul 11.
Abstract
New work from Yang et al. (https://doi.org/10.1084/jem.20242296) provides an exhaustive study of a novel mouse model of NGLY1 deficiency, a devastating neurological disease, and implicates the cGAS-STING pathway in mediating key disease features which can be rescued using an orally administered STING antagonist.
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本文引用的文献
1
Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5×FAD mice.
Nat Aging. 2023 Feb;3(2):202-212. doi: 10.1038/s43587-022-00337-2. Epub 2023 Jan 9.
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STING trafficking as a new dimension of immune signaling.
J Exp Med. 2023 Mar 6;220(3). doi: 10.1084/jem.20220990. Epub 2023 Jan 27.
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Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists.
Nat Chem. 2020 Mar;12(3):310-317. doi: 10.1038/s41557-019-0413-8. Epub 2020 Feb 10.
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