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单吻合口胃旁路术后难治性胆汁反流:一例病例报告及手术治疗的文献综述

Refractory bile reflux following one-anastomosis gastric bypass: A case report and literature review on surgical management.

作者信息

Fontaine-Nicola Andres, Cambuli-Bianchi Paula, Sadiq Kaiser O'Sahil, Carrizo Gabriel, Omelanczuk Pablo

机构信息

Department of Surgery, Division of Minimally Invasive Surgery, University of California San Diego, San Diego, CA, USA.

Department of Surgery, Division of Esophageal, Gastroduodenal and Bariatric Surgery, Italian Hospital of Mendoza, Mendoza M5519, Argentina.

出版信息

Int J Surg Case Rep. 2025 Aug;133:111642. doi: 10.1016/j.ijscr.2025.111642. Epub 2025 Jul 9.

Abstract

INTRODUCTION

Bile reflux is a recognized complication of One-Anastomosis Gastric Bypass (OAGB). Its management can be challenging, particularly when symptoms persist despite medical therapy or surgical diversion.

CASE PRESENTATION

A 46-year-old woman developed persistent bilious vomiting, nocturnal regurgitation, and aspiration following OAGB. Preoperative imaging indicated gastroesophageal reflux and a recurrent hiatal hernia. The patient underwent conversion to laparoscopic Roux-en-Y gastric bypass (LRYGB) due to her persistent symptoms and related nutritional impairment. Postoperative follow-up indicated total symptom relief and nutritional recovery thanks to the creation of the entero-enteric anastomosis.

DISCUSSION

This case illustrates the outstanding efficacy of entero-enteric diversion in specific individuals and emphasizes the importance of LRYGB in addressing refractory bile reflux, especially in the presence of anatomical considerations like hiatal hernia. The anatomical alteration of LRYGB provides functional segregation of biliopancreatic secretions, inhibiting their reflux into the esophagus.

CONCLUSION

Converting to LRYGB effectively addresses chronic biliary reflux following OAGB. In analogous situations, the evaluation of revisional surgery may save further esophageal injury and enhance quality of life.

摘要

引言

胆汁反流是单吻合口胃旁路术(OAGB)公认的并发症。其治疗可能具有挑战性,尤其是当症状在药物治疗或手术改道后仍持续存在时。

病例介绍

一名46岁女性在接受OAGB后出现持续性胆汁呕吐、夜间反流和误吸。术前影像学检查显示胃食管反流和复发性食管裂孔疝。由于患者症状持续且存在相关营养障碍,遂接受了腹腔镜Roux-en-Y胃旁路术(LRYGB)。术后随访显示,由于建立了肠-肠吻合术,症状完全缓解且营养状况恢复。

讨论

该病例说明了肠-肠改道在特定个体中的显著疗效,并强调了LRYGB在解决难治性胆汁反流方面的重要性,尤其是在存在食管裂孔疝等解剖学因素的情况下。LRYGB的解剖学改变实现了胆胰分泌物的功能分离,抑制了它们反流至食管。

结论

转为LRYGB可有效解决OAGB后的慢性胆汁反流。在类似情况下,对翻修手术的评估可能避免进一步的食管损伤并提高生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d4/12275466/37ca2d5815eb/gr1.jpg

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