某些吩噻嗪衍生物对链球菌溶血素O的保护作用。
The protective effect of some phenothiazine derivatives against streptolysin O.
作者信息
Besluau D, Gauthier-Rahman S, Halpern B
出版信息
Br J Pharmacol. 1979 Oct;67(2):173-7. doi: 10.1111/j.1476-5381.1979.tb08663.x.
Abstract
1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.
摘要
- 氯丙嗪（Cpz）和异丙嗪（Pmz）可保护小鼠免受静脉注射致死剂量的链球菌溶血素O（SLO）的伤害。其他三种吩噻嗪衍生物也有类似但较弱的作用。2. 保护作用发展缓慢；皮下注射Cpz和Pmz后4小时可获得最大保护作用。3. Cpz还可在体外抑制SLO的溶血活性。
相似文献
1
The protective effect of some phenothiazine derivatives against streptolysin O.某些吩噻嗪衍生物对链球菌溶血素O的保护作用。
Br J Pharmacol. 1979 Oct;67(2):173-7. doi: 10.1111/j.1476-5381.1979.tb08663.x.
2
Inhibitory Activity of Hydroxytyrosol against Streptolysin O-Induced Hemolysis.羟基酪醇对链球菌溶血素O诱导的溶血的抑制活性。
Biocontrol Sci. 2018;23(2):77-80. doi: 10.4265/bio.23.77.
3
Studies on antituberculotic action of some phenothiazine derivatives in vitro.某些吩噻嗪衍生物体外抗结核作用的研究。
Zentralbl Bakteriol Orig A. 1977 Dec;239(4):521-6.
4
In vivo and in vitro studies on the effects of some phenothiazines and sulpiride on kynurenine metabolism.
Biochem Pharmacol. 1982 Jul 1;31(13):2227-30. doi: 10.1016/0006-2952(82)90105-8.
5
Studies on the toxic effects of streptolysin 'O': electrocardiographic changes in mammals.链球菌溶血素“O”的毒性作用研究：哺乳动物的心电图变化
Indian J Physiol Pharmacol. 1977 Jul-Sep;21(3):199-202.
6
Inhibitory effect of phenothiazine derivatives on bone in vivo and osteoblastic cells in vitro.
Biochem Pharmacol. 1985 Nov 1;34(21):3885-9. doi: 10.1016/0006-2952(85)90439-3.
7
Comparative studies of phenothiazine derivatives for their effects on swelling of normal and sickle erythrocytes.
Gen Pharmacol. 1993 Jul;24(4):999-1006. doi: 10.1016/0306-3623(93)90179-2.
8
9
Antihemolytic, antiproteolytic and anticonvulsant properties of 10-substituted hydrazonoacetyl phenothiazines.10-取代肼基乙酰吩噻嗪的抗溶血、抗蛋白水解和抗惊厥特性。
Res Commun Chem Pathol Pharmacol. 1978 Mar;19(3):417-26.
10
Sterol structural requirements for inhibition of streptolysin O activity.抑制链球菌溶血素O活性的甾醇结构要求。
Biochem J. 1974 Apr;140(1):95-8. doi: 10.1042/bj1400095.
引用本文的文献
1
In vivo and in vitro studies of bacterial endotoxin-membrane interactions and the effects of membrane-active agents.细菌内毒素与膜相互作用及膜活性剂作用的体内和体外研究
Br J Pharmacol. 1984 Sep;83(1):15-21. doi: 10.1111/j.1476-5381.1984.tb10114.x.
2
Plasma acid phosphatase levels in endotoxaemia: modification by drugs and chemically detoxified endotoxins.内毒素血症中的血浆酸性磷酸酶水平：药物和化学解毒内毒素的影响
Br J Pharmacol. 1983 Jun;79(2):421-8. doi: 10.1111/j.1476-5381.1983.tb11015.x.
本文引用的文献
1
[Favorable action of phenothiazine derivatives on the preservation of blood].
Presse Med (1893). 1950 Oct 18;58(65):1151-3.
2
STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER.溶酶体研究。III. 链球菌溶血素O和S对兔肝颗粒组分中酸性水解酶释放的影响。
J Exp Med. 1963 Aug 1;118(2):205-22. doi: 10.1084/jem.118.2.205.
3
Effects of chlorpromazine on biological membranes--I. Chlorpromazine-induced changes in liver mitochondria.
Biochem Pharmacol. 1963 Jan;12:37-46. doi: 10.1016/0006-2952(63)90007-8.
4
Effects of chlorpromazine on biological membranes-II. Chlorpromazine-induced changes in human erythrocytes.
Biochem Pharmacol. 1963 Jan;12:47-53. doi: 10.1016/0006-2952(63)90008-x.
5
Studies on the mechanism of the lethal toxic action of streptolysin "O" and the protection by certain antiserotonin drugs.
J Lab Clin Med. 1963 Mar;61:437-52.
6
The analysis of streptococcal infections. V. Cardiotoxicity of streptolysin O for rabbits in vivo.链球菌感染的分析。五、链球菌溶血素O对家兔的体内心脏毒性。
J Exp Med. 1961 Apr 1;113(4):759-84. doi: 10.1084/jem.113.4.759.
7
[Studies on exogenous and endogenous substances acting on capillary permeability and their antagonists].[关于作用于毛细血管通透性的外源性和内源性物质及其拮抗剂的研究]
Arch Int Pharmacodyn Ther. 1959 Mar 1;119(1-2):56-101.
8
Loss of myocardial contractility induced in isolated mammalian hearts by streptolysin O.链球菌溶血素O对离体哺乳动物心脏诱导的心肌收缩力丧失。
J Exp Med. 1956 Sep 1;104(3):361-73. doi: 10.1084/jem.104.3.361.
9
The effect of phenothiazine drugs on the removal of cholinesterase from erythrocytes and on hemolysis by lysolecithin.吩噻嗪类药物对红细胞中胆碱酯酶去除及溶血卵磷脂所致溶血的影响。
Arch Biochem Biophys. 1956 Apr;61(2):335-42. doi: 10.1016/0003-9861(56)90355-1.
10
Post-nephrectomy arteriovenous fistula.
J Urol. 1967 Jul;98(1):44-7. doi: 10.1016/S0022-5347(17)62820-9.
Zotero 插件