Assessment by computed tomography of the response of pituitary macroadenomas to bromocriptine.

Eleven patients with large pituitary tumours and with extrasellar extension were studied prospectively to assess the response of these tumours to bromocriptine. Five out of the six patients with high serum prolactin due to prolactinomas showed rapid and dramatic reduction in tumour size when treated with bromocriptine. In contrast, none of the five patients with non-functioning tumours showed any change in tumour size on computed tomography.