Corenblum B, Hanley D A
Fertil Steril. 1981 Dec;36(6):716-9. doi: 10.1016/s0015-0282(16)45913-3.
Eight consecutive patients with large prolactinomas, as assessed by elevated serum prolactin concentrations and suprasellar extension of the visualized pituitary adenoma on computerized tomographic (CT) scanning, were treated with bromocriptine. With prospective evaluation all eight patients demonstrated disappearance of symptoms ascribed to both the hyperprolactinemia and the tumor itself, and all eight showed a decrease in tumor size within 3 months, as assessed by CT scanning. This prospective study demonstrates that the reduction in size of a large prolactinoma by bromocriptine is commonly observed and should be considered as an initial form of therapy for such patients.
通过血清催乳素浓度升高以及计算机断层扫描（CT）显示垂体腺瘤向鞍上扩展来评估，连续8例患有大催乳素瘤的患者接受了溴隐亭治疗。通过前瞻性评估，所有8例患者归因于高催乳素血症和肿瘤本身的症状均消失，并且通过CT扫描评估，所有8例患者在3个月内肿瘤大小均减小。这项前瞻性研究表明，溴隐亭使大催乳素瘤缩小是常见现象，应被视为这类患者的初始治疗方式。
