Bouloux P M, Grossman A, Al-Damluji S, Bailey T, Besser M
Clin Sci (Lond). 1985 Sep;69(3):365-8. doi: 10.1042/cs0690365.
The effects of naloxone (8 mg) on the pressor and plasma catecholamine response to a standard cold-pressor test have been evaluated in six normal male subjects. Plasma catecholamines were estimated by high performance liquid chromatography coupled to electrochemical detection. Cold stimulation induced significant elevations in plasma noradrenaline and adrenaline to reach mean peak levels 61% and 108% above their respective basal levels (P less than 0.05). Systolic blood pressure increased by 23 +/- 6.5 mmHg (P less than 0.001), and heart rate increased by 7.5 +/- 2.5 beats/min (P less than 0.001). Naloxone pretreatment significantly enhanced the plasma adrenaline response to the cold stimulus by 98% (P less than 0.01) with concomitant changes in peak systolic blood pressure (peak increment 31 +/- 6 mmHg) and pulse rate (12.5 +/- 3.5 beats/min) responses (both P less than 0.05). The mean plasma noradrenaline response to cold also increased after naloxone, but this failed to achieve significance. Endogenous opioids are likely to be involved in the sympathoadrenal response to a mild acute stress in man.
已在6名正常男性受试者中评估了纳洛酮（8毫克）对标准冷加压试验的升压反应和血浆儿茶酚胺反应的影响。采用高效液相色谱-电化学检测法测定血浆儿茶酚胺。冷刺激导致血浆去甲肾上腺素和肾上腺素显著升高，平均峰值水平分别比各自的基础水平高出61%和108%（P<0.05）。收缩压升高23±6.5毫米汞柱（P<0.001），心率升高7.5±2.5次/分钟（P<0.001）。纳洛酮预处理使血浆肾上腺素对冷刺激的反应显著增强98%（P<0.01），同时收缩压峰值（峰值增量31±6毫米汞柱）和脉搏率（12.5±3.5次/分钟）反应也发生变化（均P<0.05）。纳洛酮治疗后，血浆去甲肾上腺素对冷刺激的平均反应也有所增加，但未达到显著水平。内源性阿片类物质可能参与了人类对轻度急性应激的交感肾上腺反应。
