Hughes G S, Ringer T V, Francom S F, Caswell K C, DeLoof M J, Spillers C R
Upjohn Company, Kalamazoo, MI 49001.
Clin Pharmacol Ther. 1991 Nov;50(5 Pt 1):538-46. doi: 10.1038/clpt.1991.179.
The effects of fish oil and naloxone on blood pressure, catecholamines, and endorphins during the cold pressor test were evaluated in a randomized, double-blind, placebo-controlled, two-way crossover trial of normotensive and medication-free hypertensive men (n = 13 each). Subjects were given 5 gm omega-3 fatty acids per day or placebo for 30 days with a 1-month washout between interventions. The cold pressor test (hand in ice water for 5 minutes) was done at the end of the treatment periods. Intravenous naloxone (10 mg) or placebo was given before the cold pressor test. Fish oil-treated, normotensive, or hypertensive groups had similar changes in blood pressure, plasma catecholamine levels, and beta-endorphins during the cold pressor test, but naloxone treatment was associated with fivefold and tenfold increases in plasma epinephrine and cortisol levels, respectively. Naloxone may modulate sympathomedullary discharge through blockade of endorphin activity. It is unlikely that endorphins are involved in the blood pressure increase during the cold pressor test or that fish oil alters this response.
在一项针对血压正常且未服用药物的高血压男性（每组n = 13）的随机、双盲、安慰剂对照、双向交叉试验中，评估了鱼油和纳洛酮在冷加压试验期间对血压、儿茶酚胺和内啡肽的影响。受试者每天服用5克omega-3脂肪酸或安慰剂，持续30天，两次干预之间有1个月的洗脱期。在治疗期结束时进行冷加压试验（将手放入冰水中5分钟）。在冷加压试验前静脉注射纳洛酮（10毫克）或安慰剂。在冷加压试验期间，鱼油治疗组、血压正常组或高血压组的血压、血浆儿茶酚胺水平和β-内啡肽有相似的变化，但纳洛酮治疗分别使血浆肾上腺素和皮质醇水平增加了五倍和十倍。纳洛酮可能通过阻断内啡肽活性来调节交感髓质放电。内啡肽不太可能参与冷加压试验期间的血压升高，鱼油也不太可能改变这种反应。
