da Silva Brenda Evelin Barreto, Di Carlo Veronica, Minicozzi Pamela, Ssenyonga Naomi, Khan Baloch Fatima, Matz Melissa, Coleman Michel P, Allemani Claudia, Lima Carlos Anselmo
Health Sciences Graduate Programme, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
Federal University of Sergipe, Cláudio Batista Street, Aracaju, 49060- 100, Sergipe, Brazil.
Sci Rep. 2025 Jul 11;15(1):25106. doi: 10.1038/s41598-025-10659-x.
Cervical cancer remains a major public health concern in Northeast Brazil, ranking as the second most common cancer among women. This study provides the first long-term, population-based estimates of net survival from cervical cancer in Sergipe, a Brazilian state with a medium Human Development Index, using high-quality registry data subjected to rigorous quality control procedures. We analysed data for 3,977 women aged 15-99 years diagnosed with an invasive cervical cancer between 1996 and 2017 and followed up to 2022, after excluding 6,095 in situ neoplasms. Net survival was estimated using the Pohar Perme method, stratified by histological subtype and calendar period, and age-standardised with the International Cancer Survival Standard weights. We observed a substantial decline in survival over time: one-year net survival dropped from 84.6% (1996-1999) to 73.4% (2015-2017), and five-year survival from 60.8 to 49.3%. Squamous cell carcinoma and adenocarcinoma showed similar survival patterns, with five-year survival ranging from 55 to 58%. The persistent decline in net survival may reflect a shift toward more advanced or aggressive invasive cancers, as screening programmes increasingly detect and remove early-stage lesions. Delayed diagnosis and sub-optimal treatment further contribute, underscoring the need to improve screening and timely cancer care access.
宫颈癌仍是巴西东北部主要的公共卫生问题，是女性中第二常见的癌症。本研究利用经过严格质量控制程序的高质量登记数据，首次对中等人类发展指数的巴西塞尔希培州宫颈癌的净生存率进行了基于人群的长期估计。我们分析了1996年至2017年间诊断为浸润性宫颈癌且随访至2022年的3977名15 - 99岁女性的数据，排除了6095例原位肿瘤。使用波哈尔·佩尔梅方法估计净生存率，按组织学亚型和日历期分层，并采用国际癌症生存标准权重进行年龄标准化。我们观察到生存率随时间大幅下降：一年净生存率从84.6%（1996 - 1999年）降至73.4%（2015 - 2017年），五年生存率从60.8%降至49.3%。鳞状细胞癌和腺癌显示出相似的生存模式，五年生存率在55%至58%之间。净生存率的持续下降可能反映了向更晚期或侵袭性更强的浸润性癌症的转变，因为筛查计划越来越多地检测和切除早期病变。诊断延迟和治疗不充分进一步加剧了这种情况，凸显了改善筛查和及时获得癌症治疗的必要性。
