El-Andari Ryaan, Bozso Sabin, Hong Yongzhe
Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada.
Mazankowski Alberta Heart Institute, University of Alberta, 11220 83 Ave NW, Edmonton, AB, Canada.
Sci Rep. 2025 Jul 11;15(1):25047. doi: 10.1038/s41598-025-11286-2.
Following surgical repair of acute type A aortic dissection(ATAAD), distal aortic degeneration and growth may occur. Previous evidence has suggested that false lumen(FL) communications and flow may influence postoperative aortic remodeling, although the contribution of branch vessel dissection and FL communications is unclear. Patients who underwent ATAAD repair from 2017 to 2023 at a single center with at least 1 year of follow-up imaging were included in this study. Patients were grouped based on aortic pathology and surgical repair. Preoperative and postoperative measurements were taken at the level of zone 1 and between zones 4/5. 63 patients were included in this study. 87.3% received a hemiarch repair, 34.9% received hemiarch + AMDS Hybrid prosthesis, and 12.7% received a total arch replacement. Proximal aortic remodeling was not reliably predicted by the presence of FL communications or surgical approach. Distal aortic growth was independently associated with ≥ 3 or 4 visceral vessel dissections(p = 0.04 - 0.005). In conclusion, distal aortic remodeling following ATAAD repair was predicted by visceral vessel involvement. While the aortic arch is often emphasized at the time of ATAAD repair, features of the distal aorta may help to risk stratify patients for long-term adverse events, helping to guide initial management and post-ATAAD repair follow-up.
急性A型主动脉夹层(ATAAD)手术修复后,主动脉远端可能会发生退变和生长。既往证据表明,假腔(FL)连通和血流可能会影响术后主动脉重塑,尽管分支血管夹层和FL连通的作用尚不清楚。本研究纳入了2017年至2023年在单一中心接受ATAAD修复且有至少1年随访影像学资料的患者。根据主动脉病理和手术修复情况对患者进行分组。在1区水平以及4/5区之间进行术前和术后测量。本研究共纳入63例患者。87.3%接受了半弓修复,34.9%接受了半弓+AMDS混合假体修复,12.7%接受了全弓置换。FL连通的存在或手术方式并不能可靠地预测近端主动脉重塑。主动脉远端生长与≥3支或4支内脏血管夹层独立相关(p=0.04-0.005)。总之,ATAAD修复术后主动脉远端重塑可通过内脏血管受累情况进行预测。虽然在ATAAD修复时通常强调主动脉弓,但主动脉远端的特征可能有助于对患者发生长期不良事件的风险进行分层,从而有助于指导初始治疗和ATAAD修复后的随访。