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V-ATPase assembly at leaky lysosomes.

作者信息

Lystad Alf Håkon

机构信息

Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

出版信息

Nat Struct Mol Biol. 2025 Jul 11. doi: 10.1038/s41594-025-01612-7.

DOI:10.1038/s41594-025-01612-7
PMID:40646311
Abstract
摘要

相似文献

1
V-ATPase assembly at leaky lysosomes.V-ATP酶在渗漏性溶酶体中的组装。
Nat Struct Mol Biol. 2025 Jul 11. doi: 10.1038/s41594-025-01612-7.
2
Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.氨基酸可用性调节液泡H⁺-ATP酶组装。
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3
aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation.辅助蛋白协调胶质细胞中溶酶体V-ATP酶的磷酸化依赖性组装,并促进α-突触核蛋白(SNCA/α-synuclein)的降解。
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Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway.空泡型质子泵(vacuolar ATPase,V-ATPase)的调节组装在树突状细胞(dendritic cells,DCs)的成熟过程中增加,这一过程是通过由磷酸肌醇 3-激酶(phosphatidylinositol 3-kinase,PI3K)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)依赖的途径诱导的。
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Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes.质子泵 V-ATPase 抑制剂巴弗洛霉素 A1 影响 Rab7 溶酶体定位并破坏破骨细胞分泌溶酶体的顺行转运。
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AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.AKT 丝氨酸/苏氨酸激酶在哺乳动物细胞中响应氨基酸饥饿时增加 V-ATPase 依赖性溶酶体酸化。
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Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.mTORC1 通过调节 V-ATPase 组装来直接控制溶酶体的分解代谢活性。
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Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H-ATPase.非受体酪氨酸激酶ABL1通过磷酸化液泡型H-ATP酶的ATP6V1B2亚基来调节溶酶体酸化。
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Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly.黄芩素通过维持 V-ATPase 组装来减轻高脂饮食引起的肝溶酶体酸化损伤。
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Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle.溶酶体再生循环中 V-ATPase 的可逆组装和拆卸。
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本文引用的文献

1
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation.TRPML1激活后,DMXL1促进V1-ATP酶向溶酶体的募集。
Nat Struct Mol Biol. 2025 Jun 17. doi: 10.1038/s41594-025-01581-x.
2
Lysosome-associated CASM: from upstream triggers to downstream effector mechanisms.溶酶体相关的半胱氨酸天冬氨酸蛋白酶:从上游触发因素到下游效应机制
Front Cell Dev Biol. 2025 Mar 27;13:1559125. doi: 10.3389/fcell.2025.1559125. eCollection 2025.
3
The ROGDI protein mutated in Kohlschutter-Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly.
在科尔施胡特-托恩综合征中发生突变的ROGDI蛋白是Rabconnectin-3复合物的一个新亚基,与V-ATP酶组装有关。
J Biol Chem. 2025 Apr;301(4):108381. doi: 10.1016/j.jbc.2025.108381. Epub 2025 Mar 4.
4
High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles.高分辨率电子冷冻显微镜观察天然突触小泡中的 V-ATPase。
Science. 2024 Jul 12;385(6705):168-174. doi: 10.1126/science.adp5577. Epub 2024 Jun 20.
5
The H-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.H-ATP 酶(V-ATP 酶):在健康和疾病中的质子泵到信号复合物。
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C392-C414. doi: 10.1152/ajpcell.00442.2020. Epub 2020 Dec 16.
6
Structure of V-ATPase from the mammalian brain.哺乳动物脑的 V-ATPase 结构。
Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
7
Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.绘制H(+)(V)-ATP酶相互作用组图谱:鉴定参与运输、折叠、组装和磷酸化的蛋白质。
Sci Rep. 2015 Oct 7;5:14827. doi: 10.1038/srep14827.
8
Eukaryotic V-ATPase: novel structural findings and functional insights.真核生物V型ATP酶:新的结构发现与功能见解
Biochim Biophys Acta. 2014 Jun;1837(6):857-79. doi: 10.1016/j.bbabio.2014.01.018. Epub 2014 Feb 4.
9
The RAVE complex is essential for stable assembly of the yeast V-ATPase.RAVE复合体对于酵母V-ATP酶的稳定组装至关重要。
J Biol Chem. 2002 Apr 19;277(16):13831-9. doi: 10.1074/jbc.M200682200. Epub 2002 Feb 13.