Churuangsuk Chaitong, Khanungwanitkul Khanin, Kaewborisutsakul Anukoon, Kitsiripant Chanatthee, Rattanaburi Athithan, Suntornlohanakul Onnicha, Charupanit Krit, Ingviya Thammasin, Intusoma Utcharee, Puttarak Panupong
Clinical Nutrition and Obesity Medicine Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Nutrients. 2025 Jun 27;17(13):2131. doi: 10.3390/nu17132131.
: Enhanced Recovery After Surgery (ERAS) guidelines recommend preoperative carbohydrate loading; however, local hospitals often use syrup concentrate sweet drinks rather than specialized carbohydrate formulations. We compared gastric emptying, glycemic response, and fasting discomfort of a novel carbohydrate drink versus syrup concentrate sweet drinks. : In this pilot randomized, crossover trial at Prince of Songkla University Hospital, Thailand, 16 healthy volunteers received three interventions with a 1-week washout period: novel carbohydrate drink 400 mL (C400), novel carbohydrate drink 250 mL (C250), and syrup sweet drink 250 mL (SYR). The primary outcome was gastric antral cross-sectional area (CSA) measured using ultrasonography at baseline, 10, 60, 120, and 180 min post-ingestion. Secondary outcomes included glycemic response and visual analog scales for thirst and hunger. : All drinks showed comparable gastric CSA, peaking at 10 min (5.5-6.5 cm, < 0.01) and returning to baseline by 120 min. Novel carbohydrate drinks produced higher glucose peaks at 60 min (C400: 147.4 mg/dL [28.0]; C250: 148.7 mg/dL [21.7]) than SYR (123.1 mg/dL [22.4], = 0.006) with sustained elevation through 120 min. All drinks similarly reduced thirst and mouth dryness scores at 60 min ( < 0.05), though hunger increased progressively after 120 min across all groups. : Both 400 mL and 250 mL volumes of novel carbohydrate drinks demonstrated safe gastric emptying profiles comparable to syrup concentrate sweet drinks while providing more sustained glycemic responses.
术后加速康复（ERAS）指南推荐术前进行碳水化合物负荷；然而，当地医院通常使用浓缩糖浆甜饮料而非专门的碳水化合物制剂。我们比较了一种新型碳水化合物饮料与浓缩糖浆甜饮料的胃排空、血糖反应和空腹不适情况。：在泰国宋卡王子大学医院进行的这项初步随机交叉试验中，16名健康志愿者接受了三种干预措施，洗脱期为1周：400毫升新型碳水化合物饮料（C400）、250毫升新型碳水化合物饮料（C250）和250毫升糖浆甜饮料（SYR）。主要结局是在摄入后基线、10、60、120和180分钟时使用超声测量胃窦横截面积（CSA）。次要结局包括血糖反应以及口渴和饥饿的视觉模拟量表。：所有饮料的胃CSA相当，在10分钟时达到峰值（5.5 - 6.5厘米，<0.01），并在120分钟时恢复到基线。新型碳水化合物饮料在60分钟时产生的血糖峰值更高（C400：147.4毫克/分升[28.0]；C250：148.7毫克/分升[21.7]），高于SYR（123.1毫克/分升[22.4]，=0.006），且持续升高至120分钟。所有饮料在60分钟时同样降低了口渴和口干评分（<0.05），不过在120分钟后所有组的饥饿感都逐渐增加。：400毫升和250毫升的新型碳水化合物饮料均显示出与浓缩糖浆甜饮料相当的安全胃排空情况，同时提供更持久的血糖反应。
