Justyńska Weronika, Grabarczyk Mikołaj, Smolińska Ewa, Szychowska Aleksandra, Glabinski Andrzej, Szpakowski Piotr
Medical Faculty, Medical University of Lodz, 90-419 Lodz, Poland.
Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 Lodz, Poland.
Nutrients. 2025 Jul 1;17(13):2202. doi: 10.3390/nu17132202.
Polyphenols are a group of plant-derived compounds that possess a wide range of possible industrial and pharmaceutical applications. Their mechanisms of action are often enabled by their multifaceted anti-inflammatory and antioxidant properties. As a result of their promising biological profile, they have been the focus of extensive research, which has examined their potential in the treatment of various diseases. These studies have observed that polyphenols may be associated with decreased neoplastic cellular growth, therefore offering valuable potential in oncological therapies. Quercetin, luteolin, and apigenin belong to the group of polyphenols with the most documented efficacy in this regard, particularly against tumors of glial origin. This review gathers information from a multitude of in vitro investigations and animal-model-based research that explore the molecular pathways and biochemical mechanisms engaged by polyphenols which enable their anti-tumoral activity in the central nervous system. Ultimately, this article aims to summarize this research and use this data to comment on the influence of polyphenols on glioma-affected subjects, in addition to exploring methods for increasing their bioavailability for the purposes of clinical application.
多酚是一类源自植物的化合物，具有广泛的潜在工业和制药应用。它们的作用机制通常由其多方面的抗炎和抗氧化特性所驱动。由于其具有前景的生物学特性，它们一直是广泛研究的焦点，这些研究考察了它们在治疗各种疾病方面的潜力。这些研究观察到，多酚可能与肿瘤细胞生长减少有关，因此在肿瘤治疗中具有宝贵的潜力。槲皮素、木犀草素和芹菜素属于在这方面有最多文献记载疗效的多酚类，特别是对神经胶质起源的肿瘤。这篇综述收集了大量体外研究和基于动物模型的研究信息，这些研究探索了多酚参与的分子途径和生化机制，这些机制使其在中枢神经系统中具有抗肿瘤活性。最终，本文旨在总结这项研究，并利用这些数据评论多酚对受胶质瘤影响的受试者的影响，此外还探索提高其生物利用度以用于临床应用的方法。
