Chen Lijin, Lin Jingjing, Chen Xiangyu, Ma Zhimin, Du Xiaofu, Wang Meng, Chen Rong, Zhong Jieming
Department of Non-Communicable Disease Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Department of Non-Communicable and Endemic Disease Control and Prevention, Changxing Center for Disease Control and Prevention, Changxing, Huzhou 313199, China.
Nutrients. 2025 Jul 3;17(13):2210. doi: 10.3390/nu17132210.
: Although B vitamins are implicated in cardiovascular regulation, the associations between serum thiamine (vitamin B1) and blood pressure (BP) remain unclear, particularly among women who are at high risk for hypertension-related complications. This study aimed to investigate relationships between serum thiamine levels and BP outcomes among middle-aged and elderly women in eastern China. : A community-based cross-sectional study was conducted among 2015 women aged 45-69 years in Zhejiang Province, China. Serum thiamine levels were quantified using liquid chromatography tandem mass spectrometry (LC-MS/MS). Hypertension was defined as measured BP ≥ 140/90 mmHg, or current use of antihypertensive medications. Multivariate logistic and linear regression models were used to assess associations of thiamine with hypertension prevalence and BP levels, respectively. Dose-response relationships were evaluated using restricted cubic splines (RCSs). : Higher thiamine levels were significantly associated with reduced hypertension prevalence (adjusted OR per SD increase: 0.87; 95%CI: 0.77, 0.97), with RCSs confirming linear dose-response (-overall < 0.05, -nonlinearity > 0.05). Compared with the lowest tertile, participants in the highest thiamine tertile had a 25% lower hypertension risk. Thiamine levels also showed negative associations with systolic BP (adjusted coef: -1.51 mmHg per SD; 95% CI: -2.33, -0.68), with the participants in the highest tertile showing a 3.94 mmHg reduction (95%CI: -5.97, -1.92). No significant relationship was found for diastolic BP. : Serum thiamine is inversely associated with both hypertension prevalence and systolic BP in middle-aged and elderly women. This study supports the potential of serum thiamine as a modifiable biomarker in hypertension prevention strategies, particularly among aging women.
尽管B族维生素与心血管调节有关，但血清硫胺素（维生素B1）与血压（BP）之间的关联仍不明确，尤其是在高血压相关并发症高危女性中。本研究旨在调查中国东部中老年女性血清硫胺素水平与血压结果之间的关系。：在中国浙江省对2015名年龄在45 - 69岁的女性进行了一项基于社区的横断面研究。使用液相色谱串联质谱法（LC-MS/MS）对血清硫胺素水平进行定量。高血压定义为测量血压≥140/90 mmHg，或目前正在使用抗高血压药物。分别使用多变量逻辑回归和线性回归模型评估硫胺素与高血压患病率和血压水平的关联。使用受限立方样条（RCS）评估剂量反应关系。：硫胺素水平较高与高血压患病率降低显著相关（每标准差增加的调整比值比：0.87；95%置信区间：0.77，0.97），RCS证实了线性剂量反应（-总体<0.05，-非线性>0.05）。与最低三分位数相比，硫胺素最高三分位数的参与者高血压风险降低25%。硫胺素水平也与收缩压呈负相关（调整系数：每标准差-1.51 mmHg；95%置信区间：-2.33，-0.68），最高三分位数的参与者收缩压降低3.94 mmHg（95%置信区间：-5.97，-1.92）。未发现与舒张压有显著关系。：血清硫胺素与中老年女性的高血压患病率和收缩压均呈负相关。本研究支持血清硫胺素作为高血压预防策略中一个可改变的生物标志物的潜力，尤其是在老年女性中。
