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乳腺癌的核分子成像当前方法

Current Approaches of Nuclear Molecular Imaging in Breast Cancer.

作者信息

Schäfer Laura, Altunay Betül, Heesch Amelie, van Nijnatten Thiemo, Vaz Sofia, Juweid Malik Eid, Mottaghy Felix Manuel

机构信息

Department of Nuclear Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.

Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), 6229 HX Maastricht, The Netherlands.

出版信息

Cancers (Basel). 2025 Jun 23;17(13):2105. doi: 10.3390/cancers17132105.

DOI:10.3390/cancers17132105
PMID:40647404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12249193/
Abstract

In this narrative review, we aim to summarize recent advancements in nuclear molecular imaging techniques and their applications in BCa management. The main focus of this review is on the most relevant clinical investigations from the past 2-3 years that highlight the enhanced diagnostic and therapeutic value of these imaging modalities. A variety of radiolabeled probes introduced in molecular imaging is explored, detailing their roles in the accurate diagnosis and characterization of BCa, as well as their integration into radioligand therapy and theragnostic strategies.

摘要

在这篇叙述性综述中,我们旨在总结核分子成像技术的最新进展及其在膀胱癌管理中的应用。本综述的主要重点是过去两到三年中最相关的临床研究,这些研究突出了这些成像模式增强的诊断和治疗价值。我们探讨了分子成像中引入的各种放射性标记探针,详细阐述了它们在膀胱癌准确诊断和特征描述中的作用,以及它们在放射性配体治疗和诊疗策略中的整合情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5087/12249193/174ec4bb1bed/cancers-17-02105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5087/12249193/174ec4bb1bed/cancers-17-02105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5087/12249193/174ec4bb1bed/cancers-17-02105-g001.jpg

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本文引用的文献

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Beyond fluorodeoxyglucose: Molecular imaging of cancer in precision medicine.超越氟脱氧葡萄糖:精准医学中的癌症分子成像。
CA Cancer J Clin. 2025 May-Jun;75(3):226-242. doi: 10.3322/caac.70007. Epub 2025 Apr 4.
2
Prospective investigation of amino acid transport and PSMA-targeted positron emission tomography for metastatic lobular breast carcinoma.前瞻性研究氨基酸转运和 PSMA 靶向正电子发射断层扫描在转移性小叶性乳腺癌中的应用。
Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):4073-4082. doi: 10.1007/s00259-024-06830-7. Epub 2024 Jul 8.
3
The value of Ga-PSMA PET/CT in the diagnosis of intracapsular prostate cancer with a poor prognosis.
镓-前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描(Ga-PSMA PET/CT)在诊断预后不良的包膜内前列腺癌中的价值。
Discov Oncol. 2024 Jul 2;15(1):252. doi: 10.1007/s12672-024-01127-5.
4
Recent Progress of Multifunctional Molecular Probes for Triple-Negative Breast Cancer Theranostics.三阴性乳腺癌诊疗用多功能分子探针的最新进展
Pharmaceutics. 2024 Jun 14;16(6):803. doi: 10.3390/pharmaceutics16060803.
5
PET Molecular Imaging in Breast Cancer: Current Applications and Future Perspectives.正电子发射断层扫描分子成像在乳腺癌中的应用现状与未来展望
J Clin Med. 2024 Jun 13;13(12):3459. doi: 10.3390/jcm13123459.
6
Joint EANM-SNMMI guideline on the role of 2-[F]FDG PET/CT in no special type breast cancer : (endorsed by the ACR, ESSO, ESTRO, EUSOBI/ESR, and EUSOMA).EANM-SNMMI 联合指南:2-[F]FDG PET/CT 在非特殊类型乳腺癌中的作用:(由 ACR、ESSO、ESTRO、EUSOBI/ESR 和 EUSOMA 认可)。
Eur J Nucl Med Mol Imaging. 2024 Jul;51(9):2706-2732. doi: 10.1007/s00259-024-06696-9. Epub 2024 May 14.
7
Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [Ga]Ga-ABY-025: Results from a Pilot Study.人表皮生长因子受体 2(HER2)低表达乳腺癌的[Ga]Ga-ABY-025 PET 显像:一项初步研究结果。
J Nucl Med. 2024 May 1;65(5):700-707. doi: 10.2967/jnumed.123.266847.
8
Ga-FAPI PET/CT as an Alternative to F-FDG PET/CT in the Imaging of Invasive Lobular Breast Carcinoma.镓-FAPI PET/CT 可作为侵袭性小叶乳腺癌成像的 F-FDG PET/CT 替代方法。
J Nucl Med. 2024 Apr 1;65(4):512-519. doi: 10.2967/jnumed.123.266798.
9
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Eur J Nucl Med Mol Imaging. 2024 May;51(6):1713-1724. doi: 10.1007/s00259-023-06584-8. Epub 2024 Jan 13.