Gubán Renáta, Parrag Petra, Kispál Mihály Tamás, Czirbesz Kata, Danyi Tímea, Kenessey István, Liszkay Gabriella
Department of Dermato-Oncology, National Institute of Oncology and National Tumor Laboratory, 1122 Budapest, Hungary.
National Cancer Registry, National Institute of Oncology and National Tumor Laboratory, 1122 Budapest, Hungary.
Cancers (Basel). 2025 Jun 27;17(13):2171. doi: 10.3390/cancers17132171.
Over the past few decades, the incidence of melanoma has been steadily rising. In Hungary, the National Institute of Oncology serves as the national center for the diagnosis and treatment of malignancies, including melanoma. This study aims to analyze our patients' data, providing a comprehensive characterization of melanoma across the country. We systematically analyzed the clinico-pathological data of melanoma patients treated in the Department of Oncodermatology between 2001 and 2018. Prognostic parameters were collected from the Hospital Information System of the Institute, including gender, age, tumor location, exulceration of primary lesion, Clark level, and Breslow thickness. In addition, survival analysis was also performed. A total of 6267 melanoma patients were included in the study, with a slight predominance of female cases. The most common tumor location was the trunk. Female patients and younger age groups were more likely to present with lower Breslow thickness, while tumors in the head region were associated with increased thickness. Over the study period, the annual median Breslow thickness showed a significant decline. Female gender, younger age, and lower Breslow thickness was correlated with improved overall survival. Over time, the studied patient population exhibited better outcomes. Despite the rising incidence of melanoma in Hungary, the annual median Breslow thickness in our studied patient group showed a decreasing trend, accompanied by improved mortality outcomes. This highlights the critical role of secondary prevention measures and their effectiveness, as well as the impact of novel therapeutic advancements.
在过去几十年中，黑色素瘤的发病率一直在稳步上升。在匈牙利，国家肿瘤研究所是包括黑色素瘤在内的恶性肿瘤诊断和治疗的国家中心。本研究旨在分析我们患者的数据，全面描述全国范围内的黑色素瘤情况。我们系统分析了2001年至2018年期间在肿瘤皮肤病科接受治疗的黑色素瘤患者的临床病理数据。从该研究所的医院信息系统收集了预后参数，包括性别、年龄、肿瘤位置、原发皮损溃疡情况、克拉克分级和布雷斯洛厚度。此外，还进行了生存分析。共有6267例黑色素瘤患者纳入研究，女性病例略占多数。最常见的肿瘤位置是躯干。女性患者和较年轻年龄组的布雷斯洛厚度往往较低，而头部区域的肿瘤厚度增加。在研究期间，年度布雷斯洛厚度中位数呈显著下降趋势。女性、较年轻年龄和较低的布雷斯洛厚度与总体生存率提高相关。随着时间的推移，所研究的患者群体表现出更好的预后。尽管匈牙利黑色素瘤发病率上升，但我们研究的患者组年度布雷斯洛厚度中位数呈下降趋势，同时死亡率结果有所改善。这突出了二级预防措施的关键作用及其有效性，以及新型治疗进展的影响。
