Guo Xiaotong, Wang Yu, Guo Yulian, Luo Chan, Cong Keqiang
Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.
Plants (Basel). 2025 Jun 30;14(13):1994. doi: 10.3390/plants14131994.
Medikus, a pervasive weed infesting transgenic corn fields, exhibits increasing tolerance to glufosinate ammonium-a widely used herbicide in genetically modified cropping systems. This study employed a widely targeted metabolomics approach to investigate differential metabolic responses to glufosinate ammonium across two populations under identical treatments. A total of 2546 metabolites were detected, predominantly classified into alkaloids, amino acids and derivatives, and flavonoids, among other categories. Three pivotal metabolic pathways (Arginine and proline metabolism, Biosynthesis of amino acids, D-amino acid metabolism) were identified as critical regulators of herbicide response. These findings advance our understanding of weed metabolic adaptation to glufosinate ammonium and lay a foundation for elucidating potential herbicide resistance mechanisms in weeds.
Medikus是一种普遍存在于转基因玉米田中的杂草，对草铵膦（一种在转基因作物种植系统中广泛使用的除草剂）的耐受性不断增强。本研究采用广泛靶向代谢组学方法，研究在相同处理下两个种群对草铵膦的差异代谢反应。共检测到2546种代谢物，主要分为生物碱、氨基酸及其衍生物、黄酮类等类别。确定了三个关键代谢途径（精氨酸和脯氨酸代谢、氨基酸生物合成、D-氨基酸代谢）是除草剂反应的关键调节因子。这些发现增进了我们对杂草对草铵膦代谢适应性的理解，并为阐明杂草潜在的抗除草剂机制奠定了基础。
