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眼睛的光损伤:视网膜电图c波的选择性消失。

Photic damage to the eye: selective extinction of the c-wave of the electroretinogram.

作者信息

Skoog K O, Jarkman S

出版信息

Doc Ophthalmol. 1985 Oct 30;61(1):49-53. doi: 10.1007/BF00143215.

DOI:10.1007/BF00143215
PMID:4064890
Abstract

Albino rabbits were exposed to strong visible light that had passed several infrared-absorbing filters. Photic damage to the retina and pigment epithelium was studied by means of the direct current electroretinogram (dc-ERG) which allows stable registrations of the slow c-wave from the pigment epithelium as well as the relatively fast a- and b-waves from the neuroretina. The exposure to light for 4 h gave rise to striking changes in the ERG: there was only a 25% decrease in the b-wave but a total disappearance of the normally very large c-wave. At the site of the c-wave in the ERG there appeared a negative trough. The electroretinographic evidence of this study seems to indicate a profound injury to the pigment epithelium (pigment epithelial cells and/or tight junctions) after exposure to strong visible light.

摘要

将白化兔暴露于经过多个红外吸收滤光片的强光下。通过直流视网膜电图(dc - ERG)研究视网膜和色素上皮的光损伤,该方法能够稳定记录来自色素上皮的缓慢c波以及来自神经视网膜的相对快速的a波和b波。光照4小时后,ERG出现显著变化:b波仅下降25%,但通常非常大的c波完全消失。在ERG的c波部位出现一个负波谷。本研究的视网膜电图证据似乎表明,暴露于强光后色素上皮(色素上皮细胞和/或紧密连接)受到了严重损伤。

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本文引用的文献

1
Interaction of environmental light and eye pigmentation with inherited retinal degenerations.环境光和眼睛色素沉着与遗传性视网膜变性的相互作用。
Vision Res. 1980;20(12):1173-7. doi: 10.1016/0042-6989(80)90056-5.
2
Retinal irradiance from vitrectomy endoilluminators.玻璃体切割手术眼内照明器产生的视网膜辐照度。
Am J Ophthalmol. 1982 Jul;94(1):26-9. doi: 10.1016/0002-9394(82)90186-6.
3
Three major pathologic processes caused by light in the primate retina: a search for mechanisms.灵长类视网膜中由光引起的三种主要病理过程:机制探寻
Graefes Arch Clin Exp Ophthalmol. 1992;230(4):380-4. doi: 10.1007/BF00165950.
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Oxygen dependence of damage by 435 nm light in cultured retinal epithelium.培养的视网膜上皮细胞中435纳米光损伤的氧依赖性
Curr Eye Res. 1984 Jan;3(1):209-15. doi: 10.3109/02713688408997202.
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Retinal damage by light in rats.大鼠视网膜的光损伤
Invest Ophthalmol. 1966 Oct;5(5):450-73.
6
Retinal damage by visible light. An electron microscopic study.可见光对视网膜的损伤。一项电子显微镜研究。
Arch Ophthalmol. 1968 Jan;79(1):69-78. doi: 10.1001/archopht.1968.03850040071019.
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Effects of prolonged exposure of rabbit retina to low-intensity light.
Invest Ophthalmol. 1973 Jan;12(1):45-51.
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Photic maculopathy in rhesus monkey. A light and electron microscopic study.
Invest Ophthalmol. 1973 Jan;12(1):17-34.
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The c-wave of the human D.C. registered ERG. I. A quantitative study of the relationship between c-wave amplitude and stimulus intensity.人体视网膜电图直流成分的c波。I. c波振幅与刺激强度关系的定量研究。
Acta Ophthalmol (Copenh). 1974;52(5):759-73. doi: 10.1111/j.1755-3768.1974.tb01111.x.
10
Light exposure can reduce selectively or abolish the C-wave of the albino rat electroretinogram.光照可选择性地减少或消除白化大鼠视网膜电图的C波。
Invest Ophthalmol Vis Sci. 1985 Mar;26(3):388-93.