Jang Sun Woo, Lee Sang Hyub, Shin Hong Kyung, Jeon Sang Ryong, Park Danbi, Kim Chongman, Park Jin Hoon
Department of Neurological Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Republic of Korea.
Department of Neurosurgery, Spine Center, The Leon Wiltse Memorial Hospital, Suwon 16499, Republic of Korea.
J Clin Med. 2025 Jun 26;14(13):4540. doi: 10.3390/jcm14134540.
: The aim of this study was to evaluate whether the use of BioGlue increases the risk of postoperative mass formation and subsequent spinal canal invasion after intradural spinal tumor surgery. : After retrospectively reviewing patients who underwent intradural tumor surgery from 2018 to 2023, we evaluated mass formation as detected in postoperative MRI according to the Epidural Spinal Cord Compression (ESCC) grade. Patients were divided into two groups based on the use of BioGlue, and we analyzed MRI postoperatively to compare the differences in ESCC grades and the incidence of symptomatic spinal canal invasion between the two groups. Additionally, we performed a logistic regression analysis to identify risk factors associated with mass formation and to explore their relationship with BioGlue. : This study included a total of 153 patients, 87 in the BioGlue and 66 in the non-BioGlue groups. In the BioGlue group, 18 patients had ESCC grade 2, and 11 had grade 3. Conversely, in the non-BioGlue group, only 8 patients had ESCC grade 2, and none had grade 3 ( = 0.001). Among the cases of symptomatic spinal canal invasion, all five cases were identified in the BioGlue group ( = 0.001). Both univariate and multivariate analyses showed that BioGlue was a significant risk factor for spinal canal invasion (univariate: OR = 3.931, = 0.005, multivariate: OR = 3.812, = 0.003). : Our findings indicated that BioGlue was a significant risk factor for mass formation aggravating spinal canal invasion after intradural tumor surgery.
本研究的目的是评估使用生物胶是否会增加硬脊膜内脊髓肿瘤手术后形成术后肿块及随后发生椎管侵犯的风险。在回顾性分析2018年至2023年接受硬脊膜内肿瘤手术的患者后，我们根据硬膜外脊髓压迫（ESCC）分级评估术后MRI检测到的肿块形成情况。根据生物胶的使用情况将患者分为两组，我们对术后MRI进行分析，以比较两组之间ESCC分级的差异以及有症状椎管侵犯的发生率。此外，我们进行了逻辑回归分析，以确定与肿块形成相关的危险因素，并探讨它们与生物胶的关系。本研究共纳入153例患者，生物胶组87例，非生物胶组66例。在生物胶组中，18例患者的ESCC分级为2级，11例为3级。相反，在非生物胶组中，只有8例患者的ESCC分级为2级，没有患者为3级（P = 0.001）。在有症状的椎管侵犯病例中，所有5例均在生物胶组中发现（P = 0.001）。单因素和多因素分析均显示，生物胶是椎管侵犯的显著危险因素（单因素：OR = 3.931，P = 0.005，多因素：OR = 3.812，P = 0.003）。我们的研究结果表明，生物胶是硬脊膜内肿瘤手术后肿块形成加重椎管侵犯的显著危险因素。
