Levy Yochai, Golani Husam, Baya Ahmed, Pinco Erica, Koren Nira, Cojocaru Lutzy, Kagansky Dana, Kagansky Nadya
Shmuel Harofeh Geriatric Hospital, Beer Yaakov 70300, Israel.
Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
J Clin Med. 2025 Jul 1;14(13):4664. doi: 10.3390/jcm14134664.
: (CD) is the main cause of nosocomial diarrhea, resulting in increased morbidity and mortality, and is thought to be greatly affected by strict hygiene. In this study, we assessed changes in CD infection prevalence and outcomes pre- and during the COVID-19 pandemic (CP). : This was an observational cohort performed at a tertiary medical center (MC) and a geriatric hospital (GH). Patients from both hospitals diagnosed with CD were included, and the period of one year prior to the pandemic to one year after was compared. Data was extracted from electronic medical records (EMR). : A total of 145 CD-associated diarrhea (CDAD) cases were diagnosed in the MC and 54 in the GH. There was no change in CDAD prevalence or mortality between the study periods in either hospital. Disease duration, measured as days with diarrhea (DWD), was shorter during the CP in the GH (10.6 days vs. 8.1 days, < 0.01). CDAD was more prevalent in the GH during both periods; however, the disease was milder, with only three mortality cases and a significantly shorter disease duration (3.19 DWD vs. 10.67 in the MC before CP; 3.11 vs. 8.1 during CP, < 0.01). In a survival analysis for MC patients, no significant differences were found between periods before and after adjustment for age, gender and period. : The CP affected the duration but not the prevalence of CDAD. The milder course of CDAD in the GH may have been due to the quality of treatment provided in an academic GH and the subsequent faster diagnosis and treatment.
艰难梭菌（CD）是医院获得性腹泻的主要原因，会导致发病率和死亡率上升，并且被认为受到严格卫生措施的极大影响。在本研究中，我们评估了COVID-19大流行（CP）之前和期间CD感染患病率及结局的变化。：这是一项在三级医疗中心（MC）和老年医院（GH）进行的观察性队列研究。纳入了两家医院诊断为CD的患者，并比较了大流行前一年至大流行后一年的时间段。数据从电子病历（EMR）中提取。：MC共诊断出145例艰难梭菌相关性腹泻（CDAD）病例，GH诊断出54例。两家医院在研究期间CDAD的患病率或死亡率均无变化。以腹泻天数（DWD）衡量的疾病持续时间，在GH的CP期间较短（10.6天对8.1天，<0.01）。两个时期内CDAD在GH中更为普遍；然而，该病症状较轻，仅有3例死亡病例，且疾病持续时间明显较短（CP前MC为3.19 DWD对10.67；CP期间为3.11对8.1，<0.01）。在对MC患者的生存分析中，在对年龄、性别和时间段进行调整前后的时期之间未发现显著差异。：CP影响了CDAD的持续时间，但不影响其患病率。GH中CDAD病程较轻可能归因于学术性GH所提供的治疗质量以及随后更快的诊断和治疗。
