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酒精耐受性的转移及其与强化作用的关系。

The transfer of alcohol tolerance, and its relation to reinforcement.

作者信息

Rawana E, Vogel-Sprott M

出版信息

Drug Alcohol Depend. 1985 Sep;16(1):75-83. doi: 10.1016/0376-8716(85)90084-5.

Abstract

Four groups of five male social drinkers were trained on two different psychomotor tasks, a Pursuit Rotor (PR) and a Tracometer (T). They subsequently attended five drinking sessions where the same dose, 0.66 g absolute alcohol (ab alc)/kg, was administered. During these sessions, groups E and R received 'tolerance training' on the PR task by performing it under drug and receiving 25 cents reinforcement each time their score under alcohol was comparable to their drug-free level of achievement. The other two groups served as controls; group P performed the PR under alcohol but without reinforcement, and group A performed the PR with reinforcement but before alcohol was administered. The reduction of the drug-induced impairment of PR performance from Session 1-5 confirmed that groups E and R displayed significantly more tolerance than the controls. The effect of reinforcement on tolerance transfer to the T task was tested on Session 5. Groups E, P and A received reinforcement for T performance, and group R received no reinforcement. Since the E group displayed significantly more transfer of tolerance than the remaining three groups, the evidence confirmed the prediction that alcohol tolerance acquired via reinforced practice under drug transfers to a new task most readily when this reinforcement is also present.

摘要

五名男性社交饮酒者被分为四组,针对两项不同的心理运动任务进行训练,即追踪转子任务(PR)和转速计任务(T)。随后,他们参加了五次饮酒环节,每次摄入的酒精剂量均为0.66克纯酒精/千克体重。在这些环节中,E组和R组通过在服药状态下执行PR任务,并在每次酒精作用下的得分与无药状态下的成绩相当时获得25美分的强化奖励,从而接受“耐受性训练”。另外两组作为对照组;P组在饮酒状态下执行PR任务但无强化奖励,A组在饮酒前执行PR任务并获得强化奖励。从第1次到第5次环节中,药物诱导的PR任务表现受损程度降低,这证实了E组和R组比对照组表现出显著更高的耐受性。在第5次环节中测试了强化奖励对耐受性转移至T任务的影响。E组、P组和A组在T任务表现上获得强化奖励,R组未获得强化奖励。由于E组比其他三组表现出显著更多的耐受性转移,证据证实了这一预测,即当强化奖励也存在时,通过在药物作用下的强化练习获得的酒精耐受性最容易转移到新任务中。

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