Malo-Urriés Miguel, Rodríguez-Sanz Jacobo, Borrella-Andrés Sergio, Albarova-Corral Isabel, Martínez-Zamorano Juan Carlos, López-de-Celis Carlos
Department of Physiatry and Nursing, Health Sciences Faculty, University of Zaragoza, 50009 Zaragoza, Spain.
PhysiUZerapy Health Sciences Research Group, University of Zaragoza, 50009 Zaragoza, Spain.
J Clin Med. 2025 Jul 6;14(13):4772. doi: 10.3390/jcm14134772.
: Percutaneous electrolysis (PE) is an emerging therapeutic approach for tendinopathies, applying a galvanic current through a dry-needling needle to induce regenerative tissue responses. However, current dosing strategies are often empirical and lack objective physiological feedback. : This study aimed to evaluate the echogenic effects of different galvanic current intensities on cadaveric tendon tissue using quantitative ultrasound. : An ex vivo study was conducted on 29 cadaveric patellar tendon samples, each exposed to a single intensity (0-10 mA for 1 s). Quantitative ultrasound analysis was performed post-intervention, and echogenic variables were extracted using UZ eDosifier software. A composite variable, Electrolysis_UZ_Dose, was created via multiple regression to capture the overall ultrasound-visible changes. Data were analyzed using correlation, regression models, and dose-range comparisons. : An intensity-dependent response was observed in key echogenic parameters. Minimal changes occurred at low intensities (0-2 mA), whereas a progressive response emerged between 2 and 6 mA. Beyond 6 mA, a plateau effect suggested either tissue saturation or imaging limitations due to gas-induced acoustic shadowing. The Electrolysis_UZ_Dose variable strongly correlated with applied intensity (R = 0.732). : This study suggests an intensity-dependent echogenic effect of PE on tendon tissue in key ultrasound-derived parameters (A_Number, A_Area, A_Perimeter, A_Homogeneity, and A_ASM). However, as this study was conducted under experimental conditions with a single 1 s application per sample, the results should not be extrapolated to clinical practice without further validation.
经皮电解（PE）是一种用于治疗肌腱病的新兴治疗方法，通过干针施加直流电以诱导再生组织反应。然而，目前的剂量策略通常是经验性的，缺乏客观的生理反馈。本研究旨在使用定量超声评估不同直流电强度对尸体肌腱组织的回声效应。对29个尸体髌腱样本进行了一项体外研究，每个样本暴露于单一强度（0 - 10 mA，持续1秒）。干预后进行定量超声分析，并使用UZ eDosifier软件提取回声变量。通过多元回归创建了一个复合变量Electrolysis_UZ_Dose，以捕捉整体超声可见变化。使用相关性、回归模型和剂量范围比较对数据进行分析。在关键回声参数中观察到强度依赖性反应。在低强度（0 - 2 mA）时变化最小，而在2至6 mA之间出现渐进性反应。超过6 mA时，平台效应表明由于气体引起的声影导致组织饱和或成像限制。Electrolysis_UZ_Dose变量与施加强度密切相关（R = 0.732）。本研究表明，PE对肌腱组织在关键超声衍生参数（A_Number、A_Area、A_Perimeter、A_Homogeneity和A_ASM）方面具有强度依赖性回声效应。然而，由于本研究是在实验条件下进行的，每个样本仅单次施加1秒，在未经进一步验证的情况下，结果不应外推至临床实践。
