Cimino J A, Epel R, Cooperman J M
Drug Nutr Interact. 1985;3(4):201-4.
A population of mentally retarded and physically disabled individuals on long-term therapy with anticonvulsant drugs had a high prevalence of folic acid and riboflavin deficiency, 20% and 17%, respectively, as they entered an institution devoted to their care. Their previous diet was probably nutritionally marginal, as it was cooked and prepared to baby food consistency, and milk was rarely given. They were fed in the recumbent position, resulting in frequent vomiting. In this institution, a carefully planned dietary regimen that was adequate in essential nutrients was fed by trained personnel. Drug therapy was continued. After a year no signs of folic acid or riboflavin deficiency were evident. We conclude that these weak vitamin antagonists may precipitate deficiencies on marginally adequate diets. A good dietary regimen prevented the appearance of these vitamin deficiencies.
一群长期接受抗惊厥药物治疗的智力迟钝和身体残疾个体，在进入一家专门照料他们的机构时，叶酸和核黄素缺乏的患病率很高，分别为20%和17%。他们之前的饮食在营养上可能处于边缘水平，因为食物被烹饪成婴儿食品的稠度，而且很少给他们喝牛奶。他们以卧位喂食，导致频繁呕吐。在这家机构里，训练有素的工作人员提供精心规划的、必需营养素充足的饮食方案。药物治疗继续进行。一年后，叶酸或核黄素缺乏的迹象不再明显。我们得出结论，这些弱维生素拮抗剂可能会在饮食勉强充足的情况下引发缺乏症。良好的饮食方案可预防这些维生素缺乏症的出现。
