Hassan Sherif T S
Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Prague, Czech Republic.
Int J Mol Sci. 2025 Jun 20;26(13):5932. doi: 10.3390/ijms26135932.
Herpes simplex virus (HSV) is a prevalent and persistent human pathogen belonging to the family and classified as an alpha-herpesvirus. It comprises two distinct types, HSV-1 and HSV-2, which together infect a significant portion of the global population and pose substantial public health challenges. HSV-1 is typically associated with oral herpes, while HSV-2 primarily causes genital herpes; both are characterized by recurrent lesions, latent infection, and mucocutaneous discomfort. Conventional antiviral drugs such as acyclovir and its derivatives are limited by drug resistance, potential toxicity, and their inability to eradicate latent viral reservoirs. These limitations have prompted increasing interest in alternative therapeutic strategies. Phenolic acids and tannins, plant-derived polyphenolic compounds, have attracted considerable attention due to their potent antiviral properties against various viruses, including HSV. This review summarizes current research on phenolic acids and tannins as promising natural antivirals against HSV, with a focus on their mechanisms of action and efficacy in disrupting multiple stages of the HSV life cycle.
单纯疱疹病毒（HSV）是一种普遍存在且持续感染人类的病原体，属于疱疹病毒科，被归类为α疱疹病毒。它包括两种不同的类型，即HSV - 1和HSV - 2，这两种病毒共同感染了全球相当一部分人口，并带来了重大的公共卫生挑战。HSV - 1通常与口腔疱疹有关，而HSV - 2主要引起生殖器疱疹；两者都具有复发性病变、潜伏感染和黏膜皮肤不适的特征。传统的抗病毒药物如阿昔洛韦及其衍生物受到耐药性、潜在毒性以及无法根除潜伏病毒库的限制。这些局限性促使人们对替代治疗策略越来越感兴趣。酚酸和单宁是植物来源的多酚化合物，由于它们对包括HSV在内的多种病毒具有强大的抗病毒特性而备受关注。这篇综述总结了目前关于酚酸和单宁作为有前景的抗HSV天然抗病毒药物的研究，重点关注它们在破坏HSV生命周期多个阶段的作用机制和疗效。
