The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Nat Prod Res. 2023 Nov-Dec;37(24):4156-4161. doi: 10.1080/14786419.2023.2173191. Epub 2023 Jan 30.
We tested anti-herpetic effect of castalagin, an ellagitannin compound, extracted from pedunculate oak (). Previous investigations found that castalagin possesses a strong inhibitory effect against HSV-1/2 equal to acyclovir (ACV). It is also effective against ACV-resistant mutants and shows a synergistic effect with ACV. We study castalagin's activity towards HSV-1 infection in newborn mice. Acute toxicity determination in mice showed LD value of 295 mg/kg. Prolonged toxicity was also constructed. Castalagin manifested a marked activity against HSV-1 (LD/0.02 ml) administered in 7-day course at 0.02 ml s.c. doses of 7.5 or 10 mg/kg (PI 57-58%). ACV course demonstrated a marked activity at 20 mg/kg. The selectivity ratio LD/ED (295/7.5) could be accepted as ≥ 33.
我们测试了从栓皮栎中提取的鞣花单宁化合物鞣花酸对单纯疱疹病毒的抗疱疹作用。先前的研究发现，鞣花酸对 HSV-1/2 的抑制作用与阿昔洛韦（ACV）相当。它对 ACV 耐药突变体也有效，并与 ACV 具有协同作用。我们研究了鞣花酸对新生小鼠单纯疱疹病毒感染的活性。在小鼠中的急性毒性测定显示 LD 值为 295mg/kg。还构建了长期毒性。在 7 天疗程中，以 7.5 或 10mg/kg（PI 57-58%）的 0.02ml 皮下剂量给予鞣花酸（LD/0.02ml）时，对 HSV-1 表现出明显的活性（LD/0.02ml）。ACV 疗程在 20mg/kg 时表现出明显的活性。LD/ED（295/7.5）的选择性比值可以接受为≥33。
