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面向具有含硫侧链的骨化三醇类似物的多样性导向合成（DOS）

Diversity-Oriented Synthesis (DOS) Towards Calcitriol Analogs with Sulfur-Containing Side Chains.

作者信息

Gómez-Bouzó Uxía, Gómez Generosa, Fall Yagamare

机构信息

Departamento de Química Orgánica and Instituto de Investigación Sanitaria Galicia Sur (IISGS), Campus Lagoas Marcosende, Universidad de Vigo, 36310 Vigo, Spain.

出版信息

Int J Mol Sci. 2025 Jun 28;26(13):6266. doi: 10.3390/ijms26136266.

DOI:10.3390/ijms26136266
PMID:40650043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12250139/
Abstract

We report the synthesis of a very useful building block that could give pharmaceutical companies access to a series of novel calcitriol analogs, a library of compounds. This approach is called Diversity-Oriented Synthesis (DOS).

摘要

我们报道了一种非常有用的构建模块的合成，该构建模块可为制药公司提供一系列新型骨化三醇类似物，即一个化合物库。这种方法被称为导向多样性合成（DOS）。

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