Baek Kwang-Rim, Singh Saloni, Hwang Hye-Seon, Seo Seung-Oh
Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
Research Institute of Food and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
Int J Mol Sci. 2025 Jun 29;26(13):6282. doi: 10.3390/ijms26136282.
Obesity is a complex metabolic disorder with high global prevalence. Recent studies have highlighted the crucial role of gut microbiota in obesity's onset and progression. This review explores the relationship between gut microbiota composition and obesity, emphasizing how changes in microbial communities can influence host metabolism, energy balance, and fat storage. By reviewing current evidence regarding the interactions between specific microbial taxa; their metabolic byproducts, such as short-chain fatty acids; and host signaling pathways, we aim to clarify the mechanisms through which the gut microbiome contributes to obesity. Furthermore, we discuss the potential of microbiota engineering through precision strategies such as the use of probiotics, prebiotics, and genetically engineered microbial strains. Collectively, this review highlights the targeted modulation of the gut microbiome as a promising and innovative approach to the prevention and treatment of obesity.
肥胖是一种全球患病率很高的复杂代谢紊乱疾病。最近的研究强调了肠道微生物群在肥胖发生和发展中的关键作用。这篇综述探讨了肠道微生物群组成与肥胖之间的关系，着重阐述了微生物群落的变化如何影响宿主代谢、能量平衡和脂肪储存。通过回顾有关特定微生物分类群之间相互作用、它们的代谢副产物（如短链脂肪酸）以及宿主信号通路的现有证据，我们旨在阐明肠道微生物群导致肥胖的机制。此外，我们还讨论了通过精准策略（如使用益生菌、益生元及基因工程微生物菌株）进行微生物群工程改造的潜力。总的来说，这篇综述强调了对肠道微生物群进行靶向调节是预防和治疗肥胖的一种有前景的创新方法。
