Hurjui Loredana Liliana, Tarniceriu Cristina Claudia, Serban Dragomir Nicolae, Lozneanu Ludmila, Bordeianu Gabriela, Nedelcu Alin Horatiu, Panzariu Alin Constantin, Jipu Raluca, Hurjui Ruxandra Maria, Tanase Daniela Maria, Serban Ionela Lacramioara
Department of Morpho-Functional Sciences II, Physiology Discipline, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Hematology Laboratory, "Sf. Spiridon" County Clinical Emergency Hospital, 700111 Iasi, Romania.
Int J Mol Sci. 2025 Jun 30;26(13):6298. doi: 10.3390/ijms26136298.
Homocysteine (Hcy) is becoming a well-established risk factor for cardiovascular disease (CVD), mainly involving endothelial dysfunction and atherogenesis. Endothelial dysfunction is reflected primarily in the complex regulation of the main physiological and pathophysiological processes. There is increasing evidence regarding abnormally high concentrations of plasma total homocysteine, or plasma hyperhomocysteinemia, contributing to endothelial dysfunction, inflammation, and CVD. This clinical and experimental study examined the connection between Hcy and cardiovascular disease risk. Homocysteine is a marker of total vascular damage that must be monitored and controlled as early as possible. Dietary and lifestyle changes are recommended for most patients with hyperhomocysteinemia (Hhcy). The purpose of this paper is to review the data from the specialized literature that demonstrate that there is a direct link between endothelial injury and increased homocysteine levels, identifying existing evidence, describing new mechanisms, and exploring potential new therapeutic options. These aspects continue to be debated, and additional efforts are required to refine therapeutic strategies and to investigate the potential implications of Hcy in health and disease.
同型半胱氨酸（Hcy）正成为心血管疾病（CVD）公认的危险因素，主要涉及内皮功能障碍和动脉粥样硬化形成。内皮功能障碍主要体现在对主要生理和病理生理过程的复杂调节上。越来越多的证据表明，血浆总同型半胱氨酸浓度异常升高，即血浆高同型半胱氨酸血症，会导致内皮功能障碍、炎症和心血管疾病。这项临床和实验研究探讨了Hcy与心血管疾病风险之间的联系。同型半胱氨酸是血管整体损伤的一个标志物，必须尽早进行监测和控制。对于大多数高同型半胱氨酸血症（Hhcy）患者，建议改变饮食和生活方式。本文的目的是回顾专业文献中的数据，这些数据表明内皮损伤与同型半胱氨酸水平升高之间存在直接联系，识别现有证据，描述新机制，并探索潜在的新治疗选择。这些方面仍存在争议，需要进一步努力完善治疗策略，并研究Hcy在健康和疾病中的潜在影响。
