FcRL1，一种新型B细胞激活共受体。
FcRL1, a New B-Cell-Activating Co-Receptor.
作者信息
Chen Zhitao, Miao Chenxi, Zhang Yan, Huang Jiaqi, Sun Yanan, Chen Juan, Sun Jiazeng, Shi Wenbiao, Wang Xifan, Wang Ran, Li Yixuan, Zhao Xingwang
机构信息
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China.
出版信息
Int J Mol Sci. 2025 Jun 30;26(13):6306. doi: 10.3390/ijms26136306.
Fc receptor-like 1 (FcRL1), a co-receptor specifically expressed on the surface of B-cells, plays a pivotal role in modulating B-cell immune activation and orchestrating humoral immune responses. This comprehensive review systematically synthesizes research advances in FcRL1 mediated transmembrane signal transduction mechanisms, its regulatory capacity in humoral immune responses, expression patterns during B-cell differentiation and development, and expression dynamics in B-cell malignancies, while critically evaluating the therapeutic potential of FcRL1 as a cellular targeting candidate.
Fc受体样1（FcRL1）是一种在B细胞表面特异性表达的共受体，在调节B细胞免疫激活和协调体液免疫反应中起关键作用。这篇综述系统地综合了FcRL1介导的跨膜信号转导机制、其在体液免疫反应中的调节能力、B细胞分化和发育过程中的表达模式以及B细胞恶性肿瘤中的表达动态等方面的研究进展，同时批判性地评估了FcRL1作为细胞靶向候选物的治疗潜力。
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