Bekkelund Mattis, Steinsvik Elisabeth K, Valeur Jørgen, Søfteland Eirik, Dimcevski Georg, Sangnes Dag A
Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Scand J Gastroenterol. 2025 Sep;60(9):865-873. doi: 10.1080/00365521.2025.2531038. Epub 2025 Jul 12.
BACKGROUND/AIMS: Gastroparesis is a late complication of diabetes mellitus characterized by delayed gastric emptying and upper gastrointestinal symptoms. The disorder substantially impacts the quality of life, glycemic stability, nutrition and absorption of orally administered drugs. Since symptom severity is a poor predictor of gastric emptying status, the clinician has little to aid them in whom to refer for gastric emptying testing. In this study, we aim to identify clinical characteristics associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms.
Diabetes patients consecutively referred to Haukeland University Hospital for assessment of gastroparesis-like symptoms underwent gastric emptying scintigraphy, blood samples and questionnaires for assessing gastrointestinal symptoms (Gastrointestinal Symptom Rating Scale), neuroticism (Eysenck Personality Questionnaire-Short Form), and symptoms of anxiety and depression (Hospital Anxiety & Depression Scale).
Seventy-one patients were included in the study, of which 28 displayed delayed gastric emptying. Delayed gastric emptying was characterized by having type 1 diabetes, younger age, lower BMI, presence of other late complications including distal symmetric polyneuropathy and retinopathy, higher Hb1Ac levels and lower albumin and hemoglobin levels. Symptoms were not related to gastric emptying status.
We identified several clinical variables associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. These variables are commonly assessed during a medical consultation and may be used to aid the clinician in choosing who to refer for gastric emptying testing.
背景/目的：胃轻瘫是糖尿病的一种晚期并发症，其特征为胃排空延迟和上消化道症状。该病症对生活质量、血糖稳定性、营养状况以及口服药物的吸收均有重大影响。由于症状严重程度并不能很好地预测胃排空状态，临床医生在决定哪些患者需要进行胃排空测试时缺乏有效的依据。在本研究中，我们旨在确定患有类似胃轻瘫症状的糖尿病患者中与胃排空延迟相关的临床特征。
连续转诊至豪克兰大学医院评估类似胃轻瘫症状的糖尿病患者接受了胃排空闪烁扫描、血液样本采集以及用于评估胃肠道症状（胃肠道症状评分量表）、神经质（艾森克人格问卷简式）和焦虑抑郁症状（医院焦虑抑郁量表）的问卷调查。
71名患者纳入研究，其中28名显示胃排空延迟。胃排空延迟的特征包括患有1型糖尿病、年龄较小、体重指数较低、存在其他晚期并发症（包括远端对称性多发性神经病变和视网膜病变）、糖化血红蛋白水平较高以及白蛋白和血红蛋白水平较低。症状与胃排空状态无关。
我们确定了患有类似胃轻瘫症状的糖尿病患者中与胃排空延迟相关的几个临床变量。这些变量在医疗咨询期间通常会进行评估，可用于帮助临床医生决定哪些患者需要进行胃排空测试。
