Navrange Nishika, Mendes-Silva Ana Paula, Reynolds Charles F, Wetherell Julie, Mulsant Benoit, Kimmel Mary C, Lenze Eric J, Diniz Breno Satler
UConn School of Medicine, Farmington, CT, USA.
Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada.
Int Psychogeriatr. 2025 Jul 12:100113. doi: 10.1016/j.inpsyc.2025.100113.
Studies have found elevation in a key biomarker of aging (the senescence-associated secretory phenotype (SASP) index) in depression. We investigated whether sex moderates the association between the SASP and major depression in older adults.
We included 423 older adults in a current major depressive episode and 140 adults with no history of depression. We measured the plasma levels of SASP biomarkers using multiplex immunoassays. The interaction effect between sex, depression diagnosis, and senescence markers were analyzed by general linear models, adjusted for confounding variables.
Individuals with depression had a higher SASP index than the healthy comparison group (t-test= -3.902, p < 0.001). We found a significant diagnosis by sex interaction (F= 9.112, df= 1540, p = 0.003), with males with depression having the highest SASP index levels (F=20.678, df=1540, p < 0.001).
In older adults, sex plays a significant role in senescence-related changes in depression. A higher senescence burden in males with depression may be an indicator of greater vulnerability to accelerated biological aging and a marker of elevated risk of adverse outcomes in this sex.
研究发现抑郁症患者体内衰老的一个关键生物标志物（衰老相关分泌表型（SASP）指数）升高。我们调查了性别是否会调节老年人中SASP与重度抑郁症之间的关联。
我们纳入了423名处于当前重度抑郁发作期的老年人和140名无抑郁症病史的成年人。我们使用多重免疫测定法测量了SASP生物标志物的血浆水平。通过一般线性模型分析性别、抑郁症诊断和衰老标志物之间的交互作用，并对混杂变量进行了校正。
抑郁症患者的SASP指数高于健康对照组（t检验=-3.902，p<0.001）。我们发现了显著的诊断与性别的交互作用（F=9.112，自由度=1540，p=0.003），其中患有抑郁症的男性SASP指数水平最高（F=20.678，自由度=1540，p<0.001）。
在老年人中，性别在抑郁症的衰老相关变化中起重要作用。患有抑郁症的男性更高的衰老负担可能表明其更容易加速生物衰老，并且是该性别不良后果风险升高的一个标志。
