Bahadori Amir Reza, Javadnia Parisa, Naghavi Erfan, Heidaresfahani Ladan, Sarmadi Iman, Rajabi Mohammad, Davari Afshan, Dahaghin Saba, Ranji Sara, Shafiee Sajad, Tafakhori Abbas
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Neurosurg Rev. 2025 Jul 14;48(1):566. doi: 10.1007/s10143-025-03727-3.
The reports of seizures following Deep Brain Stimulation (DBS) are low; however, these seizures would be debilitating. Current literature has not provided a comprehensive analysis of seizure incidence post-DBS across various neuropsychiatric disorders. Additionally, there is a lack of insight into the contributing factors and the underlying mechanisms associated with this occurrence.
This systematic review and meta-analysis investigated the incidence of epilepsy in patients with neurological disorders who have undergone DBS, excluding those with drug-resistant epilepsy.
The study was conducted according to PRISMA guidelines and involved thorough data extraction from several databases, specifically PubMed, Scopus, Embase, Web of Science, and the Cochrane Library, until 28-Feb-2025. We performed this Meta-analysis by using Comprehensive meta-analysis (CMA) software version 3.0 for the statistical analysis Results: This systematic review and meta-analysis encompassed 33 studies, and 5,488 patients. The most frequently neurological disorder which underwent DBS in this review, was Parkinson's Disease. Our meta-analysis revealed that the incidence of seizures following DBS was 2.9% (95% CI: 0.020 to 0.042; p-value < 0.001). A strong positive correlation was identified between the rate of intracerebral hemorrhage (ICH) and seizure occurrence, with a Pearson correlation coefficient of 0.635 (p-value: 0.007). Furthermore, there is a significant increase in the likelihood of seizure occurrences following globus pallidus internus- DBS compared to subthalamic nucleus- DBS.
Patients with neurological disorders following DBS may experience seizures; however, the incidence of such occurrences is low and typically resolves spontaneously.
深部脑刺激（DBS）后癫痫发作的报告较少；然而，这些癫痫发作可能会使人衰弱。目前的文献尚未对各种神经精神疾病患者DBS术后癫痫发作的发生率进行全面分析。此外，对于导致这种情况的因素和潜在机制缺乏深入了解。
本系统评价和荟萃分析调查了接受DBS治疗的神经疾病患者（不包括耐药性癫痫患者）的癫痫发生率。
该研究按照PRISMA指南进行，涉及从多个数据库（具体为PubMed、Scopus、Embase、Web of Science和Cochrane图书馆）进行全面的数据提取，直至2025年2月28日。我们使用综合荟萃分析（CMA）软件版本3.0进行荟萃分析以进行统计分析。结果：本系统评价和荟萃分析纳入了33项研究和5488名患者。本评价中接受DBS治疗最常见的神经疾病是帕金森病。我们的荟萃分析显示，DBS后癫痫发作的发生率为2.9%（95%CI：0.020至0.042；p值<0.001）。脑内出血（ICH）发生率与癫痫发作之间存在强正相关，Pearson相关系数为0.635（p值：0.007）。此外，与丘脑底核DBS相比，苍白球内侧部DBS后癫痫发作的可能性显著增加。
接受DBS治疗的神经疾病患者可能会发生癫痫发作；然而，这种情况的发生率较低，且通常会自发缓解。
